Cdc6 Antibody

Images

 
Western Blot: Cdc6 Antibody [NB100-91692] - Extracts from HeLa cells treated with EGF 200ng/ml 30'.
Immunohistochemistry-Paraffin: Cdc6 Antibody [NB100-91692] - Paraffin-embedded human lung carcinoma tissue.

Product Details

Summary
Product Discontinued
View other related Cdc6 Primary Antibodies

Order Details


    • Catalog Number
      NB100-91692
    • Availability
      Product Discontinued

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Cdc6 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 12-63 of Human Cdc6.
Clonality
Polyclonal
Host
Rabbit
Gene
CDC6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Theoretical MW
62 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Cdc6 Lysate (NBL1-09014)

Reactivity Notes

Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cdc6 Antibody

  • CDC18LHsCDC18
  • Cdc18-related protein
  • CDC6 (cell division cycle 6, S. cerevisiae) homolog
  • CDC6 cell division cycle 6 homolog (S. cerevisiae)
  • CDC6 cell division cycle 6 homolog
  • CDC6-related protein
  • cell division control protein 6 homolog
  • cell division cycle 6 homolog (S. cerevisiae)
  • cell division cycle 6 protein
  • HsCdc18
  • HsCDC6
  • p62(cdc6)

Background

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitinconjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphasepromoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CDC6
Entrez
Uniprot