CD8 Antibody (RPA-T8) [Allophycocyanin]

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Flow Cytometry: CD8 alpha Antibody (RPA-T8) [Allophycocyanin] [NBP2-27246] - Cell surface flow cytometric analysis of CD8 in 1x106 human PBMC using 10 ul (0.1 ug) of IMG-5917G. Green represents isotype control (IMGENEX, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
RPA-T8
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

CD8 Antibody (RPA-T8) [Allophycocyanin] Summary

Immunogen
CD8 (CD8a; alpha chain)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CD8A
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1ul/1 million cells

Reactivity Notes

This product reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for CD8 Antibody (RPA-T8) [Allophycocyanin]

  • CD8
  • CD8a molecule
  • CD8A
  • LEU2
  • p32

Background

CD8 is acell surface glycoprotein expressing on thymocytes subsets and cytotoxic T cells and is either a homodimer of two alpha chains, or a heterodimer of one alpha and one beta chain. It acts as a coreceptor during T cell activation through the binding of MHC Class I molecules and is found on T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 associates with LCk with the help of a zinc clasp structure and down-regulates the production of major Th2-type cytokines. CD8 is also known to recruit pUL97 thereby inducing dissolution of the nuclear lamina and facilitating the nuclear export of viral capsids.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for CD8 alpha Antibody (NBP2-27246). (Showing 1 - 1 of 1 FAQ).

  1. The vial for this product is lacking in size and concentration information.
    • The 100 Test size vial should contain 1.0ml at 0.01mg/ml. Our recommended dilution for use is 10ul/1 x 10^6 cells (0.1ug).

Secondary Antibodies

 

Isotype Controls

Other Available Formats

DyLight 350 Labeled NBP2-25195UV
DyLight 405 Labeled NBP2-25195V
DyLight 488 Labeled NBP2-25195G
DyLight 550 Labeled NBP2-25195R
DyLight 650 Labeled NBP2-25195C
DyLight 680 Labeled NBP2-25195FR
DyLight 755 Labeled NBP2-25195IR
HRP Labeled NBP2-25195H
PE Labeled NBP2-27237
PerCP Labeled NBP2-25195PCP

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Bioinformatics Tool for CD8 alpha Antibody (NBP2-27246)

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Diseases for CD8 alpha Antibody (NBP2-27246)

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Blogs on CD8.

mTOR Signaling and the Tumor Microenvironment
By Yoskaly Lazo-Fernandez, PhD The mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that, as a member of two distinct intracellular protein complexes, mTORC1 and mTORC2, regulates protein...  Read full blog post.

The role of MHC Class II RT1B and immune response post brain injury
The major histocompatibility complex (MHC) is responsible for binding peptide fragments arising from pathogens in order to display them on the cell surface for recognition from immune cells.  Once recognized, the foreign pathogen is typically evade...  Read full blog post.

Topics in CD11b: The innate immune response
Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.  Integrin...  Read full blog post.

CD20 (Cluster of differentiation 20, Membrane-spanning 4-domains subfamily A member 1 (MS4A1), CVID5, B-lymphocyte surface antigen B1)
CD20 is a human B-lymphocyte surface molecule that spans the membrane four times and is expressed on both normal and malignant cells. The CD20 antigen displays a unique expression pattern among hematopoietic cells - it is present on human pre B-ly...  Read full blog post.

CD8 alpha - Marker for cytotoxic T lymphocytes
The T-cell co-receptor CD8 is a cell-surface glycoprotein that bridges the lipid bilayer by interacting externally with ligands, such as major histocompatibility complex (MHC) class I, as well as internally with signaling molecules such as tyrosine ki...  Read full blog post.

The CD4 Antibody: More than Just a Cellular Marker
CD4 is a member of the cluster of differentiation family of proteins, mainly expressed on the surface of thymocytes and a specific subset of mature T-cells. CD4 antibody studies have also shown it expressed on monocytes, cortical cells, microglial cel...  Read full blog post.

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Bioinformatics

Gene Symbol CD8A