CD8 alpha Antibody (FK18) Summary
The antibody reacts with CD8, the 33 kD T8 antigen present on the human cytotoxic/suppressor T-cell subset.
The antibody reacts with CD8, the 33 kD T8 antigen present on the human cytotoxic/suppressor T-cell subset. It strongly blocks the cytolytic activity of T8-positive CTLs. It also reacts with a subpopulation of Rhesus monkey lymphocytes which is identical to the population of human T8 positive cells.
Protein A or G purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Please see the vial label for concentration. If unlisted please contact technical services.
Protein A or G purified
The antibody can be used for the identification of CD8-positive cells using immunofluorescence or immunoperoxidase procedures and for the removal of CD8 positive cells using complement dependent cytotoxicity. In addition the antibody blocks the cytotoFor use in regular immunofluorescence and microcytotoxicity methods, dilution of 1:10, preferably in phosphate buffered saline plus 1% BSA and 0.02% sodium azide is advised. See for advised methods instructions A and B.
CD8a is a 32 kD glycoprotein also known as T8, Lyt2, Ly-2, and CD8 alpha. CD8a is a member of the immunoglobulin superfamily expressed on most thymocytes, subset of mature T cells, most NK cells, macrophages, and some activated CD4+ T cells (not resting). CD8a forms heterodimers with the CD8 beta chain (CD8b) on the surface of most thymocytes, while mature peripheral T lymphocytes express almost exclusively the CD8 alpha beta heterodimer. Intestinal intraepithelial lymphocytes express CD8a without CD8b. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase lck (p56lck).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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