CD5 Antibody (LT1) Summary
Normal human blood lymphocytes
Type I membrane protein
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4)
0.09% Sodium Azide
Protein G purified
- Blocking/Neutralizing 1:5000
Blocking: NB110-16583 can completely cross blocks binding of MAbs Leu1 and OKT1. It can also be used to enumerate T cells and classify cases of lymphoma.
Alternate Names for CD5 Antibody (LT1)
- CD5 antigen (p56-62)
- CD5 antigen
- CD5 molecule
- LEU1T-cell surface glycoprotein CD5
- Lymphocyte antigen T1/Leu-1
In humans, CD5 is a 67kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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