CD46 Antibody (177) Summary
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
Protein A or G purified
- Western Blot 1:100-1:2000
- Flow Cytometry 1:10-1:1000
- Immunoprecipitation 1:10-1:500
This antibody works in Flow Cytometry, Functional, Immunoassay, Immunoprecipitation, Western Blot. The typical starting working dilution is 1:10. For inhibition of biological activity in vitro dilutions have to be made according to the amounts of CD46 to be inactivated.
This product is reactive in Human
Positive control: CD46 is expressed on every cell and tissue Negative control: Erythrocytes
Alternate Names for CD46 Antibody (177)
- CD46 antigen
- CD46 molecule, complement regulatory protein
- membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
- TLXcomplement regulatory protein
- trophoblast leucocyte common antigen
- Trophoblast leukocyte common antigen
- trophoblast-lymphocyte cross-reactive antigen
The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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