CD45RB Antibody (MEM-143) Summary
Human peripheral blood lymphocytes.
The antibody MEM-143 reacts with a protein determinant of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). CD45RB is expressed on a subset of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells. The MEM-143 is therefore not neuraminidase sensitive like most other anti-CD45RB antibodies (including standard antibody MEM-55). The reactivity of the antibody MEM-143 can be blocked by a peptide including amino acids 79-88.
Protein A purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4)
15mM Sodium Azide
Protein A purified
- Flow Cytometry 4 ug/ml
- Immunohistochemistry-Paraffin 10 ug/ml
The staining pattern of the MEM-143 show prominent differences from other anti-CD45RB reagents including standard antibody MEM-55, mostly as a result of the recognition of differences in glycosylation.
Alternate Names for CD45RB Antibody (MEM-143)
- CD45 antigen
- EC 220.127.116.11
- protein tyrosine phosphatase, receptor type, C
- receptor-type tyrosine-protein phosphatase C
- T200 glycoprotein
- T200 leukocyte common antigen
- T200receptor type, c polypeptide
CD45RB is an alternatively spliced form of CD45, a cell surface glycoprotein. It is expressed on peripheral B cells, T cytotoxic cells and CD4+ T cells. It has a role in cell signalling regulation through the activation of the Src family of tyrosine kinases.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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