CD42b/GPIb alpha Antibody (VM16d)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clone
VM16d
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

CD42b/GPIb alpha Antibody (VM16d) Summary

Immunogen
The antibody reacts with the CD42b antigen.
Specificity
The monoclonal antibody is directed against the CD42b antigen, platelet glycoprotein GPIb, that serves as a receptor for von Willebrand factor and as a high affinity thrombin receptor. The antigen is expressed on human platelets and megakaryocytes. The antigen is absent or present in very low levels on platelets of patients with the Bernard-Soulier syndrome. VM16d inhibits low conc. thrombin (<0.1 U/ml) induced platelet aggregation and decreases thrombin binding to platelets. F (ab') 2 and F (ab') fragments are equally effective as whole intact antibodies. The VM16d-epitope is located within the 45 kDa N-terminal domain of GPIb alpha- chain. VM16d does not effect platelet interaction with von Willebrand factor, leading to the conclu-sion that the antibody reacts with or nearby the thrombin receptor site.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GP1BA
Purity
Ammonium sulfate precipitation
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
Analysis of platelet aggregation and detection of GPIb expression. The antibody is also useful for functional studies. The antibody is useful for indirect immunofluorescence staining with analysis by cyto-fluorometry or fluorescence microscopy.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.1 mg/ml PBS
Preservative
Sodium Azide
Concentration
LYOPH
Purity
Ammonium sulfate precipitation
Reconstitution Instructions
Reconstitute with 1 ml sterile water.

Alternate Names for CD42b/GPIb alpha Antibody (VM16d)

  • Antigen CD42b-alpha
  • BP1BA
  • BSS
  • CD42b antigen
  • CD42b
  • CD42b-alpha
  • glycoprotein Ib (platelet), alpha polypeptide
  • Glycoprotein Ibalpha
  • GP1B
  • GP1BA
  • GPIb alpha
  • GP-Ib alpha
  • GPIbA
  • GPIb-alpha
  • MGC34595
  • platelet glycoprotein Ib alpha chain
  • platelet membrane glycoprotein 1b-alpha subunit

Background

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GP1BA