Recombinant CD40 Ligand/TNFSF5 Protein Summary
A partial protein corresponding to CD40LG.
E. coli-expressed amino acids Gln103 - Leu250 (Accession # P27548).
|Details of Functionality
The ED50 measured in a T-47D cell line proliferation assay is typically 1.5 ug/ml, corresponding to a specific activity of approximately 7.5 x102 Units/mg.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
This reagent has been tested in bioassays using the cell line T-47D. The ED,50 measured in a T-47D cell proliferation assay is typically 1.5 ug/ml, corresponding to a specific activity of approximately 7.5 x10^2 Units/mg.
This protein was made to the human sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid, phosphate buffered saline, pH 7.2, with 1.0% BSA. 0.22 um filtered.
0.09% Sodium Azide
Purity: Greater than 98%, as determined by SDS-PAGE
Alternate Names for Recombinant CD40 Ligand/TNFSF5 Protein
- CD154 antigen
- CD40 antigen ligand
- CD40 Ligand
- T-B cell-activating molecule
- T-cell antigen Gp39
- TNF-related activation protein
- TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
- tumor necrosis factor (ligand) superfamily member 5
- Tumor necrosis factor ligand superfamily member 5
CD40 ligand (CD40L, also known as CD154, TRAP or gp39) is a membrane glycoprotein expressed on activated CD4+ T-cells, NK cells, mast cells, basophils and eosinophils. The CD40-CD40L interaction stimulates B cell immune responses including cell surface antigen expression, cell cycle activation, Ig isotype switching, Ig secretion and memory generation. The CD40-CD40L interaction also plays important roles in monocyte and dendritic cell activation, T-cell co-stimulation and cytokine production. It has been reported that the CD40-CD40L interaction is involved in the pathogenesis of amyloid pathology in Alzheimer disease. E. coli-produced recombinant mouse CD40L is a non-glycosylated polypeptide of 149 amino acids comprising the soluble extracellular domain of CD40L.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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