Recombinant CD40 Ligand/TNFSF5 Protein

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Summary
Product Discontinued
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    • Catalog Number
      NBP1-43179
    • Availability
      Product Discontinued

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Recombinant CD40 Ligand/TNFSF5 Protein Summary

Description
A partial protein corresponding to CD40LG.
Preparation
Method
E. Coli.
Details of Functionality
This reagent has been tested in bioassays using the cell line T-47D. The ED50 measured in a T-47D cell proliferation assay is typically 40 ng/ml, corresponding to a specific activity of approximately 2.5 x10^4Units/mg.
Protein/Peptide Type
Partial Recombinant Protein
Gene
CD40LG
Endotoxin Note
Less than 0.01 ng/ug cytokine as determined by the LAL assay.

Reactivity Notes

This protein was made to the human sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline, pH 7.2, 150 mM NaCl, with 1.0% BSA. 0.22 um filtered.
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 98%, as determined by SDS-PAGE

Alternate Names for Recombinant CD40 Ligand/TNFSF5 Protein

  • CD154 antigen
  • CD154
  • CD40 antigen ligand
  • CD40 Ligand
  • CD40-L
  • CD40LG
  • CD40LIGM
  • gp39
  • hCD40L
  • HIGM1
  • T-B cell-activating molecule
  • T-BAM
  • T-cell antigen Gp39
  • TNF-related activation protein
  • TNFSF5
  • TNFSF5IMD3
  • TRAP
  • TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
  • tumor necrosis factor (ligand) superfamily member 5
  • Tumor necrosis factor ligand superfamily member 5

Background

CD40 ligand, (CD40L, also known as CD154, TRAP or gp39) is a membrane glycoprotein expressed on activated CD4+ T-cells, NK cells, mast cells, basophils and eosinophils. The CD40-CD40L interaction stimulates B cell immune response which includes cell surface antigen expression, cell cycle activation, Ig isotype switching, Ig secretion and memory generation. The CD40-CD40L interaction also plays important roles in monocyte and dendritic cell activation, T-cell co-stimulation and cytokine production. It has been reported that the CD40-CD40L interaction is involved in the pathogenesis of amyloid pathology in Alzheimer disease. Recombinant Human CD40L produced in E.Coli is a non-glycosylated, polypeptide containing 149 amino acids and having a molecular mass of 16 kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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FAQs for CD40 Ligand/TNFSF5 Partial Recombinant Protein (NBP1-43179). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for paired ABs for use in detecting CD40L (rat) by ELISA. Do you have such a reagent(s) available?
    • Unfortunately we currently do not have any CD40 Ligand antibody pairs that have been validated in Rat. The only antibody pairs we offer for CD40L are validated in Human. I apologize for this inconvenience. If you would be interested in testing one of our products in Rat I'd like to invite you to participate in our Innovators Reward Program. Please contact us at innovators@novusbio.com with any questions regarding this program.

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Bioinformatics

Gene Symbol CD40LG
Entrez