CD38 Antibody (HIT2) [Biotin]

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Product Details

Summary
Product Discontinued
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    • Catalog Number
      NBP1-42500
    • Availability
      Product Discontinued

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CD38 Antibody (HIT2) [Biotin] Summary

Immunogen
Human thymocytes in foetus
Localization
Type II membrane protein
Specificity
The antibody HIT2 reacts with CD38 (T10), a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells. HLDA III; WS Code T 155
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CD38
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
High grade BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Fluorochrome conjugates should be stored in the dark and direct exposure to light should be avoided during handling and cell staining.

Alternate Names for CD38 Antibody (HIT2) [Biotin]

  • ADP-ribosyl cyclase 1
  • ADP-ribosyl Cyclase
  • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
  • cADPr hydrolase 1
  • CD38 antigen (p45)
  • CD38 antigen
  • CD38 molecule
  • CD38
  • Cyclic ADP-ribose hydrolase 1
  • Cyclic ADP-ribose Hydrolase
  • EC 3.2.2.5
  • NAD(+) nucleosidase
  • T10

Background

CD38 (T10) is a single chain 42 to 46 kDa type II integral transmembrane glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is expressed by murine, but not human, hematopoietic progenitors. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor. In mice, CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and is not expressed by mature plasma cells. Murine CD38 is also expressed by all Mac1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone marrow derived macrophages. This pattern of expression contrasts strikingly with that seen in the human. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of lymphomas and leukemias, inhibition of B lymphopoiesis, detection of plasma cells, protection of B cells from apoptosis, and as a marker for activated B and T cell proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for CD38 Antibody (NBP1-42500). (Showing 1 - 1 of 1 FAQ).

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CD38 is a 42 kD type II transmembrane glycoprotein that uses nicotinamide adenine dinucleotide (NAD) as a substrate to form cyclic adenosine diphosphate ribose (cADPR). This novel multifunctional ectoenzyme has both cyclase and hydrolase enzymatic act...  Read full blog post.

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Bioinformatics

Gene Symbol CD38
Entrez