CD31/PECAM-1 Antibody (MEM-05) [PE] Summary
Tissue / cell preparation (Human). (Leucocytes of patient suffering from LGL-type leukaemia).
This reacts with CD31 antigen.
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 ul reagent / 100 ul of whole blood or 10^6 cells in a suspension.
Packaging, Storage & Formulations
Store at 4C in the dark.
PBS and 0.2% (w/v) high grade BSA (protease free)
15mM Sodium Azide
Protein A or G purified
Store in the dark. Avoid prolonged exposure to light.
Alternate Names for CD31/PECAM-1 Antibody (MEM-05) [PE]
- adhesion molecule
- CD31 antigen
- PECAM-1, CD31/EndoCAM
- platelet endothelial cell adhesion molecule
- platelet/endothelial cell adhesion molecule
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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