CD28 Antibody (AV7) Summary
Chicken peripheral blood lymphocytes
Chicken CD28, a monomeric molecule of Mr 40-44 kDa with 50% amino acid sequence identity with mammalian CD28
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- Flow Cytometry 1:10 - 1:1000
- Immunohistochemistry-Frozen 1:10-1:500
- Immunoprecipitation 1:10 - 1:500
- In vitro assay
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
0.1M BBS (pH 8.2)
Alternate Names for CD28 Antibody (AV7)
- CD28 antigen (Tp44)
- CD28 antigen
- CD28 molecule
- T-cell-specific surface glycoprotein CD28
Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on Ag presenting cells. Peripheral gamma delta+ T cells are CD28-negative. (1) Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MAbs against the avian T cell receptor (TCR). Both Vbeta1- and Vbeta2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3. (2)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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