CD27/TNFRSF7 Antibody (LT27) Summary
Human peripheral blood lymphocytes
The antibody LT27 reacts with CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells. HLDA V; WS Code T T-CD27.01
Ion exchange chromatography
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Phosphate Buffered Saline (PBS), approx. pH 7.4
15mM Sodium Azide
Ion exchange chromatography
Alternate Names for CD27/TNFRSF7 Antibody (LT27)
- CD27 antigen
- CD27 molecule
- S152CD27L receptor
- T cell activation antigen CD27
- T cell activation antigen S152
- TNFRSF7T-cell activation antigen CD27
- Tumor necrosis factor receptor superfamily member 7
- tumor necrosis factor receptor superfamily, member 7
CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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