CD27/TNFRSF7 Antibody (CLB-27)

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Product Details

Summary
Product Discontinued
View other related CD27/TNFRSF7 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-42308
    • Availability
      Product Discontinued

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CD27/TNFRSF7 Antibody (CLB-27) Summary

Immunogen
E-rossette positive human lymphocytes.
Specificity
The monoclonal antibody is directed against the CD27 antigen, a 55 kD protein, which is expressed on a large subpopulation (75%) of peripheral blood T-lymphocytes and most medullary thymocytes. Little binding was observed with normal human B-cells, CD3 negative leukemic cells, B-cells derived and myeloid leukemias.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CD27
Purity
Ammonium sulfate precipitation
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
Identification of two functionally distinct populations within the CD4+ T-cell sub­set.The antibody is useful for indirect immunofluorescence staining with analysis by cytofluoro­metry or fluorescence microscopy.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
No Preservative
Purity
Ammonium sulfate precipitation

Alternate Names for CD27/TNFRSF7 Antibody (CLB-27)

  • CD27 antigen
  • CD27 molecule
  • CD27
  • MGC20393
  • S152CD27L receptor
  • T cell activation antigen CD27
  • T cell activation antigen S152
  • T14
  • TNFRSF7
  • TNFRSF7T-cell activation antigen CD27
  • Tp55
  • Tumor necrosis factor receptor superfamily member 7
  • tumor necrosis factor receptor superfamily, member 7

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Additional CD27/TNFRSF7 Products

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Bioinformatics

Gene Symbol CD27
Entrez