CD27/TNFRSF7 Antibody (CLB-27) Summary
E-rossette positive human lymphocytes.
The monoclonal antibody is directed against the CD27 antigen, a 55 kD protein, which is expressed on a large subpopulation (75%) of peripheral blood T-lymphocytes and most medullary thymocytes. Little binding was observed with normal human B-cells, CD3 negative leukemic cells, B-cells derived and myeloid leukemias.
Ammonium sulfate precipitation
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Please see the vial label for concentration. If unlisted please contact technical services.
Ammonium sulfate precipitation
Identification of two functionally distinct populations within the CD4+ T-cell subset.The antibody is useful for indirect immunofluorescence staining with analysis by cytofluorometry or fluorescence microscopy.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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