CD161 Antibody (10/78) [Alexa Fluor® 405] Summary
Purified splenic NK cells from the LEW rat strain
Detects rat CD161 in ELISAs.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
|Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CD161 Antibody (10/78) [Alexa Fluor® 405]
- CD161 antigen
- CLEC5BC-type lectin domain family 5 member B
- killer cell lectin-like receptor subfamily B member 1
- killer cell lectin-like receptor subfamily B, member 1
- Natural killer cell surface protein P1A
CD161, also known as KLRB1, NK1.1, and NKR-P1A is a 40 kDa
type II transmembrane glycoprotein that contains one C-type lectin domain in
its extracellular region. CD161 is expressed as a disulfide-linked dimer on the
surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T
cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic
cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated
cytotoxicity and IFN-gamma secretion. Alternatively, CD161 can enhance TCR
activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative
colitis, Grave's disease, and AIDS, although CD161+ T cells are activated
during asthmatic attacks. Additional related proteins are expressed in mouse
but not human: the inhibitory NKR-P1B and D, and the stimulatory NKR-P1A, C,
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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