CD160 Antibody (CNX46-3)

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Product Details

Summary
Product Discontinued
View other related CD160 Primary Antibodies

Order Details


    • Catalog Number
      NBP2-00192
    • Availability
      Product Discontinued

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CD160 Antibody (CNX46-3) Summary

Immunogen
The immunogen for this antibody is CD160.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
CD160
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunoprecipitation 1:10-1:500
Application Notes
This CNX46-3 (CNX46-3) antibody has been tested by flow cytometric analysis of C57BL/6 mouse splenocyte suspensions. This can be used at less than or equal to 1 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. This CNX46-3 antibody has also been reported for use in immunoprecipitation and immunoblotting (WB). It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous, may contain carrier protein/stabilizer.
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for CD160 Antibody (CNX46-3)

  • BY55
  • BY55FLJ46513
  • CD160 antigenimmunoglobulin superfamily member
  • CD160 molecule
  • CD160
  • Natural killer cell receptor BY55
  • NK1
  • NK28

Background

CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCR?d T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, crosslinking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CD160
Entrez