CD117/c-kit Antibody

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Immunohistochemistry-Paraffin: CD117/c-kit Antibody [NB110-55526] - Analysis of anti-c-Kit antibody with human spleen, central artery and lymphocytes within periarteriolar lymphoid sheaths at 20 ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-55526
    • Availability
      Product Discontinued

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CD117/c-kit Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from extracellular domain of human c-Kit.
Epitope
Extracellular domain of human
Marker
Hematopoietic Stem Cell Marker
Specificity
Human c-Kit. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Monkey (94%). Backed by our 100% Guarantee.
Clonality
Polyclonal
Host
Rabbit
Gene
KIT
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 20 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Marmoset (88%), Mouse (88%), Rat (88%), Hamster (81%), Porcine (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CD117/c-kit Antibody

  • CD117 antigen
  • CD117
  • ckit
  • c-kit
  • EC 2.7.10
  • EC 2.7.10.1
  • KIT
  • PBT
  • piebald trait
  • Proto-oncogene c-Kit
  • proto-oncogene tyrosine-protein kinase Kit
  • SCF R
  • SCFR
  • SCFRmast/stem cell growth factor receptor
  • soluble KIT variant 1
  • Tyrosine-protein kinase Kit
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Background

KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Somatic gain-of-function mutations in the extracellular domain, kinase domains 1 and 2 are found in gastrointestinal stromal tumors (GISTs). Mutations in c-KIT gene are also associated with mast cell disease, acute myelogenous lukemia, and piebaldism. Tyrosine kinase inhibitor STI571 has been shown to inhibit GIST cells that express mutated c-KIT.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics Tool for CD117/c-kit Antibody (NB110-55526)

Discover related pathways, diseases and genes to CD117/c-kit Antibody (NB110-55526). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for CD117/c-kit Antibody (NB110-55526)

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PTMs for CD117/c-kit Antibody (NB110-55526)

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Research Areas for CD117/c-kit Antibody (NB110-55526)

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Blogs on CD117/c-kit.

Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene...  Read full blog post.

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Bioinformatics

Gene Symbol KIT
Entrez