CD117/c-kit Antibody (SP26) Summary
Synthetic peptide corresponding to cytoplasmic domain of human CD117 protein
Hematopoietic Stem Cell Marker
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
This product is useful for Immunohistochemistry Paraffin. Antigen retrieval can be performed using a Citrate process.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
7.0 ml prediluted tissue culture supernatant with 1.0% BSA
Protein A or G purified
For a positive control use Breast carcinoma.
Alternate Names for CD117/c-kit Antibody (SP26)
- CD117 antigen
- EC 2.7.10
- EC 22.214.171.124
- piebald trait
- Proto-oncogene c-Kit
- proto-oncogene tyrosine-protein kinase Kit
- SCF R
- SCFRmast/stem cell growth factor receptor
- soluble KIT variant 1
- Tyrosine-protein kinase Kit
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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Additional CD117/c-kit Products
Bioinformatics Tool for CD117/c-kit Antibody (NBP1-49797)
Discover related pathways, diseases and genes to CD117/c-kit Antibody (NBP1-49797). Need help?
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Blogs on CD117/c-kit.
Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene... Read full blog post.