CD117/c-kit Antibody (SP26)

Images

 
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - Human GI stromal tumor
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - CD117/c-kit
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - Human Gastrointestinal Stromal Tumor
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - Human Melanoma
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - Human Bladder Transitional Cell Carcinoma
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - Human Bladder
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (SP26) [NBP1-49797] - Human Colon

Product Details

Summary
Product Discontinued
View other related CD117/c-kit Primary Antibodies

Order Details


    • Catalog Number
      NBP1-49797
    • Availability
      Product Discontinued

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CD117/c-kit Antibody (SP26) Summary

Immunogen
Synthetic peptide corresponding to cytoplasmic domain of human CD117 protein
Marker
Hematopoietic Stem Cell Marker
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
KIT
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This product is useful for Immunohistochemistry Paraffin. Antigen retrieval can be performed using a Citrate process.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
7.0 ml prediluted tissue culture supernatant with 1.0% BSA
Preservative
Sodium Azide
Purity
Protein A or G purified

Notes

For a positive control use Breast carcinoma.

Alternate Names for CD117/c-kit Antibody (SP26)

  • CD117 antigen
  • CD117
  • ckit
  • c-kit
  • EC 2.7.10
  • EC 2.7.10.1
  • KIT
  • PBT
  • piebald trait
  • Proto-oncogene c-Kit
  • proto-oncogene tyrosine-protein kinase Kit
  • SCF R
  • SCFR
  • SCFRmast/stem cell growth factor receptor
  • soluble KIT variant 1
  • Tyrosine-protein kinase Kit
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Background

c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional CD117/c-kit Products

Bioinformatics Tool for CD117/c-kit Antibody (NBP1-49797)

Discover related pathways, diseases and genes to CD117/c-kit Antibody (NBP1-49797). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for CD117/c-kit Antibody (NBP1-49797)

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PTMs for CD117/c-kit Antibody (NBP1-49797)

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Research Areas for CD117/c-kit Antibody (NBP1-49797)

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Blogs on CD117/c-kit.

Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene...  Read full blog post.

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Bioinformatics

Gene Symbol KIT
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