CD117/c-kit Antibody (1C5)

Images

 
Western Blot: CD117/c-kit Antibody (1C5) [NBP2-22182] - Western blot analysis using c-Kit mouse mAb against Jurkat (1) and Hela (2) cell lysate.
Immunohistochemistry-Paraffin: CD117/c-kit Antibody (1C5) [NBP2-22182] - Immunohistochemical analysis of paraffin-embedded gastrointestinal stromal tumor using c-Kit mouse mAb with DAB staining.
Western Blot: CD117/c-kit Antibody (1C5) [NBP2-22182] - Western blot analysis using c-Kit mAb against human KIT (AA: 805-976) recombinant protein. (Expected MW is 45 kDa)
ELISA: CD117/c-kit Antibody (1C5) [NBP2-22182] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clone
1C5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

CD117/c-kit Antibody (1C5) Summary

Immunogen
Purified recombinant fragment of human c-Kit expressed in E. Coli.
Marker
Hematopoietic Stem Cell Marker
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KIT
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:10000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:200-1:1000
Theoretical MW
145 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.03% Sodium Azide
Purity
Unpurified

Alternate Names for CD117/c-kit Antibody (1C5)

  • CD117 antigen
  • CD117
  • ckit
  • c-kit
  • EC 2.7.10
  • EC 2.7.10.1
  • KIT
  • PBT
  • piebald trait
  • Proto-oncogene c-Kit
  • proto-oncogene tyrosine-protein kinase Kit
  • SCF R
  • SCFR
  • SCFRmast/stem cell growth factor receptor
  • soluble KIT variant 1
  • Tyrosine-protein kinase Kit
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Background

The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics Tool for CD117/c-kit Antibody (NBP2-22182)

Discover related pathways, diseases and genes to CD117/c-kit Antibody (NBP2-22182). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on CD117/c-kit.

Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene...  Read full blog post.

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Bioinformatics

Gene Symbol KIT
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