CCR7 Antibody (3D12) [PE] Summary
The immunogen for this antibody was CCR7.
Protein A or G purified
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- Flow Cytometry 1:10-1:1000
This 3D12 antibody has been tested by flow cytometric analysis of human peripheral blood cells. This can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test. It is recommended that the staining incubation time be increased to at least 45 minutes at 4°C for optimal staining.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
0.09% Sodium Azide
Protein A or G purified
Alternate Names for CCR7 Antibody (3D12) [PE]
- BLR2C-C chemokine receptor type 7
- C-C CKR-7
- CD197 antigen
- CDw197CC chemokine receptor 7
- chemokine (C-C motif) receptor 7
- CMKBR7chemokine (C-C) receptor 7
- EBI1EBV-induced G protein-coupled receptor 1
- EBV-induced G-protein coupled receptor 1
- Epstein-Barr virus induced gene 1
- Epstein-Barr virus induced G-protein coupled receptor
- Epstein-Barr virus-induced G-protein coupled receptor 1
- lymphocyte-specific G protein-coupled peptide receptor
- MIP-3 beta receptor
The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of nave from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DCs. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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