CCR6 Antibody (4C6)

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Western Blot: CCR6 Antibody (4C6) [NBP1-04271] - Cell lysates of Raji (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CCR6 (1:500). Proteins were visualized using a goat ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clone
4C6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

CCR6 Antibody (4C6) Summary

Immunogen
Recombinant human CCR6 (1-46aa) purified from E. coli
Specificity
Anti-human CCR6 mAb, clone 4C6, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CCR6 protein.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CCR6
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • ELISA 1:100-1:2000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 10% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for CCR6 Antibody (4C6)

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • CMKBR6STRL22
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPR-CY4
  • GPRCY4DRY-6
  • lymphocyte, 22
  • STRL22

Background

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CCR6
Entrez
Uniprot