CCR5 Antibody [DyLight 650]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications ELISA, Flow, Func, ICC/IF, In vitro
Clonality
Polyclonal
Host
Rabbit

CCR5 Antibody [DyLight 650] Summary

Immunogen
A synthetic peptide demonstrating a high affinity towards the monoclonal CCR5 2D7. This peptide is known as the 2D7-2SK peptide and consists of the following residues: EWQKEGLVTLWLGGGGSC.
Localization
Membrane; multi pass membrane protein.
Specificity
This antibody is specific for the linear epitope detected by the monoclonal antibody 2D7.
Clonality
Polyclonal
Host
Rabbit
Gene
CCR5
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 650
Format
DyLight 650 (A=652, E=672)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • ELISA 1 ug/ml
  • Flow Cytometry 25 ug/ml
  • Functional
  • Immunocytochemistry/Immunofluorescence 1:100
  • In vitro assay
Application Notes
This CCR5 antibody may be used for Western blot, ELISA, Immunocytochemistry/Immunofluorescence and Flow Cytometry, as well as being useful for inhibition of CCR5 tropic HIV envelope mediated fusion, syncytia formation, and infection in various in vitro assays.

Reactivity Notes

Rhesus Monkey.

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CCR5 Antibody [DyLight 650]

  • C-C CKR-5
  • C-C motif chemokine receptor 5 A159A
  • CCCKR5
  • CC-CKR-5FLJ78003
  • CCR5
  • CCR-5
  • CD195 antigen
  • CD195
  • chemokine (C-C motif) receptor 5
  • chemokine receptor CCR5
  • CHEMR13
  • CKR5
  • CKR-5
  • HIV-1 fusion coreceptor
  • IDDM22CMKBR5C-C chemokine receptor type 5

Background

The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for CCR5 Antibody (NB100-531C) (0)

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Secondary Antibodies

 

Isotype Controls

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Blogs on CCR5

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol CCR5
Entrez

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