CCR10/GPR2 Antibody

Product Discontinued

CCR10/GPR2 Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from 2nd extracellular domain of human CCR10.
• Specificity: Human CCR10. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Bovine (94%), Rabbit (94%), Monkey (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CCR10
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 9 - 44 ug/ml
• Control:

  CCR10/GPR2 Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (94%), Panda (94%), Gibbon (88%), Mouse (88%), Rat (88%), Hamster (88%), Elephant (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCR10/GPR2 Antibody

• CC chemokine receptor 10
• C-C chemokine receptor type 10
• C-C CKR-10
• CC-CKR-10
• CCR10
• CCR-10
• chemokine (C-C motif) receptor 10
• G protein-coupled receptor 2
• GPR2
• GPR2G-protein coupled receptor 2

Background

GPR2/CCR10, a Chemokine Receptor, encodes a protein that most closely resembles the interleukin-8 receptor. The keratinocyte-produced chemokine CCL27 activates CCR10 and is involved in T cell-mediated skin inflammation. GRP2/CCR10 has been reported to be ubiquitously expressed. Transcripts for this receptor have been identified in peripheral tissues including adult small intestine and fetal liver, testis, placenta, and skin. In the skin, this receptor is constitutively expressed in melanocytes, fibroblasts, and microvascular endothelial cells. It is also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in keratinocytes (Homey et al., 2000), dendritic cells, or in various brain regions (Marchese et al., 1994). ESTs have been isolated from brain, eye, and kidney libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCR10/GPR2 Antibody (NLS1152)(1)

Publication using NLS1152

• Pacheco-Rodriguez G, Kumaki F, Steagall WK et al. Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. J Immunol. 2009-02-01 [PMID: 19155472] (IHC-P, Human)
  
  Details:
  IHC(paraffin), human lung tissue, Fig. Supp 1: 1. IMG-71201 (CCR1), Fig. 1D.

Bioinformatics

• Gene Symbol: CCR10
• Entrez:
  • 2826(Human)
• Uniprot:
  • P46092()