CCR1 Antibody [FITC]

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Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications ELISA
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

Order Details

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Catalog# & Conjugate Size Price

CCR1 Antibody [FITC] Summary

Immunogen
Synthetic peptide taken within amino acid region 1-50 on mouse CCR1 protein.
Specificity
The antibody does not cross reacts with other members of the CCR family.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CCR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:10000
Application Notes
NBP1-78178 is ideal for ELISA applications, other applications have not been tested. These antibodies do not cross react to other chemokine receptors. The species cross reactivity for this antibody is not fully examined.
Publications
Read Publication using NBP1-78178.

Reactivity Notes

The CCR1 peptides sequences were conserved in rat, mouse and human protein and also present in other species.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris/Glycine buffer pH 7.5-7.9, stabilizing protein, and glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CCR1 Antibody [FITC]

  • C-C chemokine receptor type 1
  • CC-CKR-1
  • CCR1
  • CCR-1
  • CD191 antigen
  • CD191
  • chemokine (C-C motif) receptor 1
  • CKR1
  • CKR-1
  • CMKBR1SCYAR1
  • CMKR1
  • HM145C-C CKR-1
  • LD78 receptor
  • Macrophage inflammatory protein 1-alpha receptor
  • MIP-1alpha-R
  • MIP1aR
  • RANTES receptor
  • RANTES-R

Background

Chemokine receptors represent a subfamily of ~20 GPCRs that were originally identified by their roles in immune cell trafficking. Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and RANTES, members of the beta chemokine family of leukocyte chemo-attractants, bind to a common seven-transmembrane-domain human receptor. Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CCR) belong to the superfamily of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and directing the proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases. Induction of chemokines and infiltration of chemokine receptor-bearing cells has also been shown in a variety of animal models of renal diseases, as well as in human diseases and allograft rejection (2) Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Several subtypes of CCR have been characterized (CCR1-CCR9). The CCR1 receptors are activated by its ligand CCL5/RANTES and control cell migration associated with routine immune surveillance, inflammation and development. CCR1 also plays important role in normal physiology, cancer and AIDS, thus making them important therapeutic targets. The CCR1 receptor protein is approximately 45 kDa (355 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The CCR4 receptors are activated by Thymus and activation-regulated chemokine (TARC) that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CCR1-selective antibodies were generated against conserved but unique sequences from human and mouse CCR1 proteins. These sequences reside near the N-terminal end of CCR1 and are unique to CCR1 protein. The antibodies to CCR1 are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. The affinity purified antibodies are also conjugated to FITC and biotin for direct applications in IHC and cell sorting experiments.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Mu, Rt
Applications: ELISA

Publications for CCR1 Antibody (NBP1-78178)(1)


Showing Publication 1 - 1 of 1.
Publication using NBP1-78178 Applications Species
Tran PB, Miller RJ. Nat Rev Neurosci. 4:444-55. 2003 [PMID: 12778117]

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Blogs on CCR1.

CCR1 (C-C chemokine receptor type 1)
Chemokines play a central role in inflammation and are crucial for recruitment of immune cells to sites of infection. The chemokine-dependent activation of leukocytes occurs through binding to G-protein coupled receptors. These chemokine receptor s...  Read full blog post.

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Bioinformatics

Gene Symbol CCR1
Entrez