CCM2 Antibody (2E4)

Images

 
Western Blot: CCM2 Antibody (2E4) [NBP2-01133] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CCM2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ...read more
Immunocytochemistry/ Immunofluorescence: CCM2 Antibody (2E4) [NBP2-01133] Staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2.
Immunohistochemistry-Paraffin: CCM2 Antibody (2E4) [NBP2-01133] - Staining of paraffin-embedded Human Kidney tissue using anti-CCM2 mouse monoclonal antibody.

Product Details

Summary
Product Discontinued
View other related CCM2 Primary Antibodies

Order Details


    • Catalog Number
      NBP2-01133
    • Availability
      Product Discontinued

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CCM2 Antibody (2E4) Summary

Immunogen
Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CCM2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CCM2 Antibody (2E4)

  • C7orf22OSM
  • cerebral cavernous malformation 2
  • Cerebral cavernous malformations 2 protein
  • chromosome 7 open reading frame 22
  • malcavernin
  • MGC4067
  • MGC4607
  • MGC74868

Background

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for CCM2 Antibody (NBP2-01133)

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Diseases for CCM2 Antibody (NBP2-01133)

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Bioinformatics

Gene Symbol CCM2
Entrez