Recombinant CCL5/RANTES Protein

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Immunoassay: RANTES Protein [NBP1-42878] - Chemotaxis of mouse CCR5-transfected CHO cell line in response to Mouse CCL5 (RANTES) Recombinant Protein Carrier-Free

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42878
    • Availability
      Product Discontinued

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Recombinant CCL5/RANTES Protein Summary

Description
A partial protein corresponding to CCL5.
Preparation
Method
E. coli derived (Ser24-Ser91) accession number NM_013653
Details of Functionality
The bioactivity of this protein was determined by transmigration assay of mCCR5-transfected CHO cells. The ED50 for this effect is 1-5 ng/ml. This corresponds to a specific activity of 1 x 10^6 - 2 x 10^5Units/mg.
Protein/Peptide Type
Partial Recombinant Protein
Gene
CCL5
Endotoxin Note
Less than 0.01 ng/ug of cytokine as determined by the LAL assay.

Reactivity Notes

This protein was made to the mouse sequence.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sterile liquid, 0.1 M glycine, pH 3.0, 0.22 &um filtered
Preservative
0.09% Sodium Azide

Notes

Purity: Greater than 98% as determined by SDS-PAGE

Alternate Names for Recombinant CCL5/RANTES Protein

  • CCL5
  • chemokine (C-C motif) ligand 5
  • D17S136Enormally T-expressed, and presumably secreted
  • EoCP
  • Eosinophil chemotactic cytokine
  • RANTES
  • SISd
  • SIS-delta
  • small inducible cytokine A5 (RANTES)
  • small inducible cytokine subfamily A (Cys-Cys), member 5
  • Small-inducible cytokine A5
  • T cell-specific protein P228
  • T-cell specific protein p288
  • TCP228T-cell-specific protein RANTES

Background

Mouse CCL-5, or RANTES (regulated on activation normal T cell expressed and secreted), is an 8 kDa monomeric protein that belongs to the CC- family of chemokines. The chemokines in this family share a common g-protein coupled receptor, CCR5, which they bind to through a conserved core region. In humans, CCR5 is also known to be the co-receptor through which the HIV virus enters the cell. This effect is blocked by the binding of RANTES to CCR5, making these proteins potential targets for HIV therapy. RANTES plays an important role in the immune response by initiating the recruitment of leukocytes to the site of inflammation. It is a chemoattractant for T cells, monocytes, and dendritic cells, and may increase the cytotoxicity and promote proliferation of NK cells. It is reported to be produced by fibroblasts, platelets, and T cells. RANTES is also involved in the progression and metastasis of some forms of cancer, and constitutive expression has been demonstrated in some malignant tumors. Human and mouse RANTES share 85% sequence homology and demonstrate cross-species activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol CCL5
Entrez