CCL5/RANTES Partial Recombinant Protein Summary
A partial protein corresponding to CCL5.
E. coli derived (Ser24-Ser91) accession number NM_013653
|Details of Functionality
The bioactivity of this protein was determined by transmigration assay of mCCR5-transfected CHO cells. The ED50 for this effect is 1-5 ng/ml. This corresponds to a specific activity of 1 x 10^6 - 2 x 10^5Units/mg.
Less than 0.01 ng/ug of cytokine as determined by the LAL assay.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid, 0.1 M glycine, pH 3.0, 0.22 &um filtered
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This protein was made to the mouse sequence.
Purity: Greater than 98% as determined by SDS-PAGE
Alternate Names for CCL5/RANTES Partial Recombinant Protein
- chemokine (C-C motif) ligand 5
- D17S136Enormally T-expressed, and presumably secreted
- Eosinophil chemotactic cytokine
- small inducible cytokine A5 (RANTES)
- small inducible cytokine subfamily A (Cys-Cys), member 5
- Small-inducible cytokine A5
- T cell-specific protein P228
- T-cell specific protein p288
- TCP228T-cell-specific protein RANTES
Mouse CCL-5, or RANTES (regulated on activation normal T cell expressed and secreted), is an 8 kDa monomeric protein that belongs to the CC- family of chemokines. The chemokines in this family share a common g-protein coupled receptor, CCR5, which they bind to through a conserved core region. In humans, CCR5 is also known to be the co-receptor through which the HIV virus enters the cell. This effect is blocked by the binding of RANTES to CCR5, making these proteins potential targets for HIV therapy. RANTES plays an important role in the immune response by initiating the recruitment of leukocytes to the site of inflammation. It is a chemoattractant for T cells, monocytes, and dendritic cells, and may increase the cytotoxicity and promote proliferation of NK cells. It is reported to be produced by fibroblasts, platelets, and T cells. RANTES is also involved in the progression and metastasis of some forms of cancer, and constitutive expression has been demonstrated in some malignant tumors. Human and mouse RANTES share 85% sequence homology and demonstrate cross-species activity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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