CCK-A R Antibody

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Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

CCK-A R Antibody Summary

Immunogen
Peptide with sequence C-KFDASQKKSAKEKR corresponding to internal region according to Uniprot Mouse NP_033957.1.
Epitope
KFDASQKKSAKEKR
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CCKAR
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Peptide ELISA Detection limit 1:64000
Application Notes
WB: Approx. 75 kDa band observed in purified membranes of rat insulinoma cell line RIN14B (PMID: 20011057). The observed MW also corresponds to earlier findings in scientific literature with different antibodies (PMID: 14566022).
Publications
Read Publications using NB100-60552.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rabbit.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCK-A R Antibody

  • CCK1R
  • CCK1-R
  • CCK-A R
  • CCK-A receptor
  • CCK-A
  • CCKAR
  • CCK-AR
  • CCKRA
  • cholecystokinin A receptor
  • cholecystokinin receptor type A
  • cholecystokinin type-A receptor
  • Cholecystokinin-1 receptor

Background

The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCK-A R Antibody (NB100-60552)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CCKAR
Entrez
Uniprot