Catenin alpha 1/2 Antibody

Images

 
Western Blot: Catenin alpha 1/2 Antibody [NB100-91684] - Extracts from Hela cell.
Immunohistochemistry-Paraffin: Catenin alpha 1/2 Antibody [NB100-91684] - Paraffin-embedded human lung carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-91684
    • Availability
      Product Discontinued

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Catenin alpha 1/2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids C-terminus of Human Catenin-alpha2.
Clonality
Polyclonal
Host
Rabbit
Gene
CTNNA1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Catenin-alpha 1/2 (P940) pAb in extracts from Hela cell.
Immunohistochemistry (IHC) analyzes of Catenin-alpha 1/2 (P940)pAb in paraffin-embedded human lung carcinoma tissue
Theoretical MW
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Catenin alpha 1 Lysate (NBL1-09575)

Reactivity Notes

Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Catenin alpha 1/2 Antibody

  • Alpha E-catenin
  • alpha-catenin
  • alpha-E-catenin
  • alphaE-catenin
  • cadherin-associated protein
  • CAP102
  • catenin (cadherin-associated protein), alpha 1 (102kD)
  • catenin (cadherin-associated protein), alpha 1, 102kDa
  • catenin alpha-1
  • FLJ36832
  • FLJ52416
  • Renal carcinoma antigen NY-REN-13

Background

alpha E-catenin (also designated alpha-catenin; cadherin-associated protein, alpha 1, 102kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via beta- or gamma-catenin and Actin. alpha E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. alpha E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, and is thus considered a contributing factor to metastasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Bioinformatics Tool for Catenin alpha 1/2 Antibody (NB100-91684)

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Bioinformatics

Gene Symbol CTNNA1
Entrez