Caspase-8 Antibody

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Western Blot: Caspase 8 Antibody [NBP1-45447] - Western blot analysis of capsase-8 in Jurkat cell treated by camptothecin.

Product Details

Summary
Product Discontinued
View other related Caspase-8 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-45447
    • Availability
      Product Discontinued

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Caspase-8 Antibody Summary

Immunogen
Synthetic peptide surrounding amino acid 392 of mouse caspase-8.
Clonality
Polyclonal
Host
Rabbit
Gene
CASP8
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Western blotting (0.5-4 ug/ml). The immunoaffinity purified antibody detects the full length (55 kDa), intermediate cleavage fragments (26-31 kDa) and cleaved large fragment (18 kDa) of caspase-8.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2), 0.5% BSA and 30% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for Caspase-8 Antibody

  • AIS
  • androgen receptor
  • CASP8
  • Caspase8
  • Caspase-8
  • DHTRTFM
  • Dihydrotestosterone receptorHYSP1
  • HUMARA
  • Mch5
  • NR3C4KD
  • Nuclear receptor subfamily 3 group C member 4
  • SMAX1SBMA
  • spinal and bulbar muscular atrophy

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Caspase-8 Antibody (NBP1-45447). (Showing 1 - 1 of 1 FAQ).

  1. May we ask the MW difference between the active form and the proform of Caspase 8 while performing WB?
    • In treated cells induced to undergo apoptosis, caspase-8 migrates as a 55/53 kDa (pro-form), 41/42 kDa (a cleaved/active or intermediate form), and 18 kDa (active form). The proform (55/53 kDa) is still seen in treated cells because not all cells undergo apoptosis at once.

Secondary Antibodies

 

Isotype Controls

Additional Caspase-8 Products

Bioinformatics Tool for Caspase-8 Antibody (NBP1-45447)

Discover related pathways, diseases and genes to Caspase-8 Antibody (NBP1-45447). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Caspase-8 Antibody (NBP1-45447)

Discover more about diseases related to Caspase-8 Antibody (NBP1-45447).
 

Pathways for Caspase-8 Antibody (NBP1-45447)

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PTMs for Caspase-8 Antibody (NBP1-45447)

Learn more about PTMs related to Caspase-8 Antibody (NBP1-45447).

Blogs on Caspase-8.

Caspase 3, the executioner of apoptosis
Caspase-3 enzyme is a member of the family of endoproteases which regulate inflammation and apoptosis signaling networks. Caspase-3 is known as an executioner caspase in apoptosis because of its role in coordinating the destruction of cellular stru...  Read full blog post.

VPS41 - An important regulator of lysosomal trafficking
Membrane fusion is an essential step during the trafficking of endosomes and vesicles throughout the cell. Membrane fusion events are facilitated by multisubunit tethering complexes (MTC) including CORVET and HOPS. These complexes interact with Rab...  Read full blog post.

Caspase-8 - a pro-apoptotic protein with dynamic roles in normal physiology and pathology
Caspases are a family of cysteine-aspartic acid proteases that are responsible for the initiation and execution of apoptosis. Caspase-8 is a 55 kDa protein expressed as an inactive procaspase that resides in the cytosol. Activation of Caspase-8 req...  Read full blog post.

Caspase 8 - a key mediator of apoptosis
Programmed cell death via apoptosis is a key controlled physiological process instigated by the cell death receptor family, their ligands, and the caspase cysteine protease family. All caspases exist in a precursor form that contains a prodomain, a...  Read full blog post.

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Bioinformatics

Gene Symbol CASP8
Entrez
Uniprot