Caspase-4 Antibody

Images

 
Western Blot: Caspase-4 Antibody [NBP1-51267] - Analysis of Caspase 4 (E124) pAb at 1:500 dilutionLane1:Hela whole cell lysate(40ug)Lane2:The Liver tissue lysate of Rat(40ug)Lane3:The Liver tissue lysate of Mouse(40ug)
Immunohistochemistry-Paraffin: Caspase-4 Antibody [NBP1-51267] - Analyzes of Caspase 4 (E124) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Western Blot: Caspase 4 Antibody [NBP1-51267] - Analyzes of Caspase 4 (E124) pAb in extracts from K562 cells.
Immunohistochemistry-Paraffin: Caspase 4 Antibody [NBP1-51267] - Analyzes of Caspase 4 (E124) pAb in paraffin-embedded human lung carcinoma tissue.

Product Details

Summary
Product Discontinued
View other related Caspase-4 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51267
    • Availability
      Product Discontinued

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Caspase-4 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human Caspase 4.
Specificity
Caspase-4 (E124) pAb detects endogenous levels of Caspase-4 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
CASP4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analyzes of Caspase-4 (E124) pAb in extracts from K562 cells.
Immunohistochemistry (IHC) analyzes of Caspase-4 (E124) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Caspase-4 Antibody

  • apoptotic cysteine protease Mih1/TX
  • CASP4
  • CASP-4
  • caspase 4, apoptosis-related cysteine peptidase
  • caspase 4, apoptosis-related cysteine protease
  • Caspase4
  • Caspase-4
  • EC 3.4.22
  • EC 3.4.22.57
  • ICE(rel)II
  • ICE(rel)-II
  • ICEREL-II
  • ICH2
  • ICH-2
  • Mih1/TX
  • Protease ICH-2
  • Protease TX
  • TX

Background

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is comprised of caspase- 1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, and caspase-10. Ced- 3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the 112 kDa nuclear protein PARP into an 85 kDa apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Blogs on Caspase-4.

Caspase-4 - a human protease with roles in inflammation and immunity
Caspases are a family of cysteine-aspartic acid proteases that cleave caspase proenzymes as well as other protein substrates. Caspases are well known for their role in apoptosis, but they also play a significant role in other cellular processes inc...  Read full blog post.

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Bioinformatics

Gene Symbol CASP4
Entrez