Caspase-4 Antibody


Western Blot: Caspase-4 Antibody [NBP1-51267] - Analysis of Caspase 4 (E124) pAb at 1:500 dilutionLane1:Hela whole cell lysate(40ug)Lane2:The Liver tissue lysate of Rat(40ug)Lane3:The Liver tissue lysate of Mouse(40ug)
Immunohistochemistry-Paraffin: Caspase-4 Antibody [NBP1-51267] - Analyzes of Caspase 4 (E124) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Western Blot: Caspase 4 Antibody [NBP1-51267] - Analyzes of Caspase 4 (E124) pAb in extracts from K562 cells.
Immunohistochemistry-Paraffin: Caspase 4 Antibody [NBP1-51267] - Analyzes of Caspase 4 (E124) pAb in paraffin-embedded human lung carcinoma tissue.

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Caspase-4 Antibody Summary

Synthetic peptide, corresponding to amino acids 100-150 of Human Caspase 4.
Caspase-4 (E124) pAb detects endogenous levels of Caspase-4 protein.
Immunogen affinity purified
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  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analyzes of Caspase-4 (E124) pAb in extracts from K562 cells.
Immunohistochemistry (IHC) analyzes of Caspase-4 (E124) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for Caspase-4 Antibody

  • apoptotic cysteine protease Mih1/TX
  • CASP4
  • CASP-4
  • caspase 4, apoptosis-related cysteine peptidase
  • caspase 4, apoptosis-related cysteine protease
  • Caspase4
  • Caspase-4
  • EC 3.4.22
  • EC
  • ICE(rel)II
  • ICE(rel)-II
  • ICH2
  • ICH-2
  • Mih1/TX
  • Protease ICH-2
  • Protease TX
  • TX


A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is comprised of caspase- 1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, and caspase-10. Ced- 3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the 112 kDa nuclear protein PARP into an 85 kDa apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Caspase-4 - a human protease with roles in inflammation and immunity
Caspases are a family of cysteine-aspartic acid proteases that cleave caspase proenzymes as well as other protein substrates. Caspases are well known for their role in apoptosis, but they also play a significant role in other cellular processes inc...  Read full blog post.

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Gene Symbol CASP4