Caspase-12 Antibody

Images

 
Western Blot: Caspase-12 Antibody [NBP1-51247] - Analysis of Caspase 12 (P99) pAb in extracts from HUVEC cells.
Immunohistochemistry-Paraffin: Caspase-12 Antibody [NBP1-51247] - Human heart tissue.

Product Details

Summary
Product Discontinued
View other related Caspase-12 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51247
    • Availability
      Product Discontinued

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Caspase-12 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 65-123 of Human Caspase 12.
Specificity
Caspase12 (P99) pAb detects endogenous levels of Caspase12 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
CASP12
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Caspase12 (P99) pAb in extracts from HUVEC cells.
Immunohistochemistry (IHC) analyzes of Caspase12 (P99) pAb in paraffin-embedded human heart tissue.
Theoretical MW
42 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Caspase-12 Antibody

  • Apoptosis Related Cysteine Protease
  • CASP 12
  • CASP12
  • CASP12P1
  • Caspase 12 pseudogene 1
  • Caspase12
  • Caspase-12
  • UNQ9415

Background

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase- 5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics Tool for Caspase-12 Antibody (NBP1-51247)

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Blogs on Caspase-12.

Caspase-12 - activator of apoptosis via the ER stress response
Aside from their important role in apoptosis, caspases also play an important role in inflammatory processes. Humans express four inflammatory caspases: Caspase-1, -4, -5, and -12. Caspase-12 is a 48 kDa protein localized to the ER and involved in...  Read full blog post.

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Bioinformatics

Gene Symbol CASP12
Entrez