Caspase-10/FLICE2 Antibody


Western Blot: Caspase-10/FLICE2 Antibody [NB100-91683] - Analysis of Caspase 10 (K442) pAb at 1:500 dilution Lane1:Hela whole cell lysate(30ug) Lane2:Hela treated with H2O2 (100nmol/ml, 25min, phostop) whole cell lysate more
Immunohistochemistry-Paraffin: Caspase-10/FLICE2 Antibody [NB100-91683] - Analyzes of paraffin-embedded human breast carcinoma tissue at 1:100.
Western Blot: Caspase-10/FLICE2 Antibody [NB100-91683] - Extracts from Hela cell.
Immunohistochemistry-Paraffin: Caspase-10/FLICE2 Antibody [NB100-91683] - Paraffin-embedded human lung carcinoma tissue.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
1.0 mg/ml

Order Details

Caspase-10/FLICE2 Antibody Summary

Synthetic peptide, corresponding to amino acids 410-462 of Human Caspase 10.
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline, pH 7.2.
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


Application Notes
Western blot (WB) analysis of Caspase 10 (K442) pAb in extracts from Hela cell.
Immunohistochemistry (IHC) analyzes of Caspase 10 (K442)pAb in paraffin-embedded human lung carcinoma tissue The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
59 kDa

Alternate Names for Caspase-10/FLICE2 Antibody

  • Apoptotic protease Mch-4
  • CASP10
  • CASP-10
  • caspase 10, apoptosis-related cysteine peptidase
  • caspase 10, apoptosis-related cysteine protease
  • Caspase10
  • caspase-10
  • EC
  • FADD-like ICE2
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2
  • FLICE2
  • ICE-like apoptotic protease 4
  • interleukin-1B-converting enzyme 2
  • Mch4


Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Blogs on Caspase-10/FLICE2.

Caspase 10 - an initiator caspase in the extrinsic death receptor pathway
Apoptosis, also called programmed cell death, is an essential process in development and disease. The signaling networks that carry out apoptosis is consists of a series of endoproteases called caspases which are synthesized as inactive zymogens....  Read full blog post.

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