Carboxyl Methyl Lysine Antibody

Product Discontinued

Carboxyl Methyl Lysine Antibody Summary

• Immunogen: Carboxy methyl Lysine conjugated to KLH.
• Specificity: This specifically binds to Carboxy methyl Lysine modified proteins.
• Clonality: Polyclonal
• Host: Rabbit
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1/200 - 1/20000
  • Western Blot 1/200 - 1/20000

Reactivity Notes

All Species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 75mM PBS (pH 7.2), 75mM NaCl and 1.0mM EDTA
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Carboxyl Methyl Lysine Antibody

• CML

Background

N epsilon carboxymethyl lysine (CML) is formed by the non enzymatic Schiff base reaction of glucose with proteins, followed by an Amadori rearrangement and oxidation that leaves only a carboxymethyl group attached to the lysine. The levels of CML adducts accumulate over time and have been used as an indicator of both serum glucose levels and oxidative protein damage. Elevated serum CML modified proteins have been associated with diabetes and may contribute to diabetic retinopathy, nephropathy and angiopathy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Carboxyl Methyl Lysine Antibody (NB600-1337)(1)

Publication using NB600-1337

• de Souza Pinto R, Castilho G, Paim BA. Inhibition of macrophage oxidative stress prevents the reduction of ABCA-1 transporter induced by advanced glycated albumin. Lipids 2012-05-01 [PMID: 22271422]