CaMKIV Antibody

Images

 
Western Blot: CaMKIV Antibody [NB300-288] - A) Detection of CamK4 by Western blot in Jurkat WCE (5, 15, 50 ug) and HeLa WCE (50 ug) using NB300-288 (0.04 ug/ml). B) Immunoprecitation of CamK4 using various CamK4 ...read more
Immunohistochemistry-Paraffin: CaMKIV Antibody [NB300-288] - Human ovarian carcinoma. Antibody used at a dilution of 1:1,000 (0.2ug/ml).

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB300-288
    • Availability
      Product Discontinued

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CaMKIV Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 425 and the C-terminus (residue 473) of human Calcium/Calmodulin-dependent Protein Kinase IV using the numbering given in Swiss-Prot entry Q16566 (GeneID 814).
Clonality
Polyclonal
Host
Rabbit
Gene
CAMK4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:5000-1:15000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 3-5 ug/mg lysate
Positive Control
CaMKIV Lysate (NBL1-08666)

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CaMKIV Antibody

  • brain Ca(2+)-calmodulin-dependent protein kinase type IV
  • brain Ca++-calmodulin-dependent protein kinase type IV
  • calcium/calmodulin-dependent protein kinase IV
  • calcium/calmodulin-dependent protein kinase type IV catalytic chain
  • calcium/calmodulin-dependent protein kinase type IV
  • CAM kinase- GR
  • CAM kinase IV
  • CaM kinase-GR
  • CaMK IV
  • caMK
  • CaMK-GR
  • EC 2.7.11
  • EC 2.7.11.17
  • IV
  • MGC36771

Background

Ca2+/calmodulin dependent protein kinase type 4 (CaMK4, formerly known as CaM kinase Gr) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase. CaMK4 is highly expressed in cell and tissue extracts such as the brain, lymphocytes, spleen, neurons, thymus and testes. This kinase has two isoforms, a catalytically active calmodulin dependent kinase or a testes specific calmodulin binding protein, calspermin, generated by alternative splicing from the same gene. CaMK4 appears to require another kinase (CaMKK) to stimulate it. CaMK4, in a calcium and calmodulin dependent manner, is implicated in phosphorylating transcription factors including the CCAAT enhancer binding protein (C/EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium dependent gene expression. In neurons, CaMK4 is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T cells (NFAT). CaMK4 is encoded, along with calspermin, by the CaMK4 gene. It has been found that in testes, CaMK4 is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for CaMKIV Antibody (NB300-288)

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Bioinformatics

Gene Symbol CAMK4
Entrez
Uniprot