CAD Antibody


Western Blot: CAD Antibody [NBP1-77001] - Mouse lung (L) and kidney (K) tissue lysates with CAD antibody at 1:500 dilution.
Immunocytochemistry/ Immunofluorescence: CAD Antibody [NBP1-77001] - Staining of CAD in mouse kidney tissue with CAD antibody at 5 ug/ml.
Immunohistochemistry: CAD Antibody [NBP1-77001] - Staining of CAD in mouse kidney tissue with CAD antibody at 5 ug/ml.
Immunocytochemistry/ Immunofluorescence: CAD Antibody [NBP1-77001] - Immunofluorescence of CAD in Mouse Kidney cells with CAD antibody at 10 ug/mL.
Immunohistochemistry-Paraffin: CAD Antibody [NBP1-77001] - Mouse kidney tissue with CAD antibody at 1 ug/ml.

Product Details

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CAD Antibody Summary

Antibody was raised against a 16 amino acid peptide near the carboxy terminus of murine CAD. The immunogen is located within the last 50 amino acids of CAD.
Immunogen affinity purified
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  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 10 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
CAD antibody antibody can be used for detection of CAD by Western blot at 1:500 to 1:1000 dilution. A 40 kDa band should be detected.

Reactivity Notes


Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified

Alternate Names for CAD Antibody

  • CAD protein
  • CAD trifunctional protein
  • carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, anddihydroorotase
  • EC
  • EC
  • EC 6.3.5
  • EC
  • multifunctional protein CAD


Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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