C4 binding protein A Antibody

Product Discontinued

C4 binding protein A Antibody Summary

• Immunogen: Human C4BP purified from plasma
• Specificity: Specific for C4 binding protein.This product gives a single arc against human plasma when tested by IEP. Identity was confirmed by double diffusion against human plasma and a known anti-human C4BP.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: C4BPA
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:20-1:200
• Control:

  C4 binding protein A Overexpression Lysate

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Glycine ed saline (pH 7.4), 0.01% Benzamidine, 0.1% EACA and 1.0mM EDTA
• Preservative: 0.09% Sodium Azide
• Purity: IgG purified

Alternate Names for C4 binding protein A Antibody

• C4b binding protein, alpha chain
• C4b-binding protein alpha chain
• C4BP
• complement component 4 binding protein, alpha chain
• complement component 4 binding protein, alpha
• complement component 4-binding protein, alpha
• Proline-rich protein
• PRP

Background

C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa, beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C4BPA
• Entrez:
  • 722(Human)
• Uniprot:
  • P04003(Human)