c-Rel Antibody

Images

 
Western Blot: c-Rel Antibody [NB100-91951] - Western blot (WB) analysis of c-Rel (N497) Antibody in extracts from MDA-MB-435 cells.
Immunohistochemistry: c-Rel Antibody [NB100-91951] - Immunohistochemistry (IHC) analyzes of c-Rel (N497) Antibody in paraffin-embedded human breast carcinoma tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-91951
    • Availability
      Product Discontinued

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c-Rel Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 470-520 of Human c-Rel.
Clonality
Polyclonal
Host
Rabbit
Gene
REL
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of c-Rel (N497) pAb in extracts from MDA-MB-435 cells.
Immunohistochemistry (IHC) analyzes of Rel (N497) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
78 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

This antibody is reactive against Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for c-Rel Antibody

  • C-Rel proto-oncogene protein
  • cRel
  • c-Rel
  • I-Rel
  • oncogene REL, avian reticuloendotheliosis
  • proto-oncogene c-Rel
  • REL
  • v-rel avian reticuloendotheliosis viral oncogene homolog
  • v-rel reticuloendotheliosis viral oncogene homolog (avian)

Background

c-Rel is the cellular cognate of v-Rel, the avian reticuloendotheliosis virus strain T transforming gene. v-Rel encodes a phosphoprotein that is located in the cytoplasm of transformed spleen cells and in the nucleus of non-transformed fibroblasts, in contrast to the c-Rel protein, which is cytoplasmic. c-Rel has been shown to represent a constituent of the kappaB site binding transcription factor NFkappaB, which plays a crucial role in the expression of immunoglobulin kappa light chain gene. In contrast to c-Rel, v-Rel is truncated in its C-terminal transactivation domain and does not appear to function as a transcriptional transactivator. It has thus been postulated that v-Rel may interfere with the normal transcription of NFkappaB regulated genes and thus cause transformation by a mechanism analogous to v-ErbA, which binds to the thyroid hormoneresponsive region in certain erythroid genes needed for differentiation, but cannot be activated by thyroid hormone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Array NB100-91951

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Research Areas for c-Rel Antibody (NB100-91951)

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Blogs on c-Rel.

NFkB and p62 Both Activate and Regulate Inflammation
Nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) is a protein complex that regulates DNA transcription and is a critical regulator of cell survival. NFkB has long been known as a primer of inflammation, however researchers are...  Read full blog post.

RelA/NF-kB - A proinflammatory signaling pathway with roles in immunity and cancer
The inflammatory response consists of a complex network of signaling pathways that regulate a diverse set of cytokines, growth factors, adhesion molecules, and transcription factors (1). Of the proinflammatory signaling pathways the NF-kB family is...  Read full blog post.

Nuclear Factor kappa B Signaling in the Immune System
Nuclear Factor kappa B (NFkB) binds to the kappa-beta site of the immunoglobulin kappa light chain gene enhancer. Thus NFkB has become one of the widely studied transcription factors in innate and adaptive immune responses. The NFkB family is composed...  Read full blog post.

Recombinant Monoclonal Antibodies

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Bioinformatics

Gene Symbol REL
Entrez
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