C-Reactive Protein/CRP Antibody (B893M)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42811
    • Availability
      Product Discontinued

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C-Reactive Protein/CRP Antibody (B893M) Summary

Immunogen
Purified human C-Reactive Protein.
Specificity
C-Reactive Protein
Isotype
IgG2b Lambda
Clonality
Monoclonal
Host
Mouse
Gene
CRP
Purity
Protein A purified
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Applications/Dilutions

Application Notes
Specific methodologies have not been tested using this product. Purification: >98% pure (SDS-PAGE). Protein A chromatography and gel filtration Kd = 2 x 10-8 M

Reactivity Notes

Human C Reactive Protein

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM Sodium Phosphate (pH 7.4) and 0.15M NaCl
Preservative
0.1% Sodium Azide
Concentration
5.99 mg/ml
Purity
Protein A purified

Alternate Names for C-Reactive Protein/CRP Antibody (B893M)

  • C-Reactive Protein
  • C-reactive protein, pentraxin-related
  • CRP
  • MGC88244
  • pentraxin 1
  • PTX1MGC149895

Background

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CRP
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