c-Myc Blocking Peptide

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Product Details

Summary
Reactivity HuSpecies Glossary
Concentration
1.0 mg/ml

Order Details

c-Myc Blocking Peptide Summary

Description
A peptide to MYC.
Protein/Peptide Type
Blocking Peptide
Gene
MYC

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
dH2O
Concentration
1.0 mg/ml

Alternate Names for c-Myc Blocking Peptide

  • avian myelocytomatosis viral oncogene homolog
  • BHLHE39
  • bHLHe39MRTL
  • Class E basic helix-loop-helix protein 39
  • cMyc
  • c-Myc
  • myc proto-oncogene protein
  • Myc
  • Myc2
  • MYCC
  • myc-related translation/localization regulatory factor
  • Niard
  • Nird
  • Proto-oncogene c-Myc
  • Transcription factor p64
  • v-myc avian myelocytomatosis viral oncogene homolog
  • v-myc myelocytomatosis viral oncogene homolog (avian)

Background

The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation. In addition, deregulated expression of c-Myc induces apoptosis in different cell types, with c-myc requiring p53 for apoptosis in many cell types. This fact indicates heterogeneous mechanisms for c-myc-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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NB600-336PEP
Species: Hu

Publications for c-Myc Peptide (NB600-336PEP) (0)

There are no publications for c-Myc Peptide (NB600-336PEP).
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FAQs for c-Myc Peptide (NB600-336PEP). (Showing 1 - 3 of 3 FAQ).

  1. What is the size of this protein in kDa?
    • This peptide was used to generate our c-Myc antibody NB600-336. This is just the c-Myc epitope tag so it's only about 1kDa. This peptide is intended to be a blocking peptide rather than for use in Western blot. 9E10 is also a commercial available antibody against the c-Myc tag, so this should work just fine.
  2. What is the sequence?
    • Our sequence is considered proprietary, but we utilized a synthetic peptide made to the human c-Myc protein (between residues 400-450). Residues 400-450 contains the region used universally to c-Myc tag proteins.
  3. Has this peptide been used as an absorption control for immunostaining with the c-myc antibody clone 9E10? What is the effective concentration of peptide per ml of optimally diluted antibody? Are there any punblications citing this procedure?
    • Our c-Myc peptide NB600-336PEP is a blocking peptide specific to our c-Myc antibody NB600-336. The NB600-336PEP peptide is a synthetic peptide made to the human c-Myc protein (between residues 400-450) [UniProt P01106]. We have tested this peptide in a western blot competition assay with our NB600-336 antibody. We used the peptide at a 50-200 molar excess of the antibody. This translates to approximately 5-10ug of peptide to every 1ug of antibody. Currently, we do not have any published reference using this peptide.

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Bioinformatics Tool for c-Myc Peptide (NB600-336PEP)

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Blogs on c-Myc. Showing 1-10 of 14 blog posts - Show all blog posts.

The role of c-Fos in the regulation of the JC virus gene transcription
c-Fos is a member of the AP-1 transcription factor family under the Fos protein family umbrella, alongside Fra-1, Fra-2 and Fos-B.  Also in the AP-1 transcription family are the Jun proteins, c-Jun, Jun-B and Jun-D.  Each member of the AP-1 transcri...  Read full blog post.

Dual applications of a c-Myc antibody in mitochondrial research
c-Myc, a proto-oncogene, has documented involvement in cellular differentiation, cell growth, cell death and tumor formation.  Target genes of the Myc family include those that participate in cell survival, translation, transcription, metabolism and...  Read full blog post.

MAPK8/JNK1 - A multifunctional kinase and drug target for cancer therapeutics
The c-Jun N-terminal kinase (JNK) family is a group of regulatory kinases with important functions in cell morphogenesis, inflammation, differentiation, and cell death (1). Aberrant activation of JNK family proteins in cancers has led to interest i...  Read full blog post.

MYC - A human oncogene with valuable laboratory applications
Myc is a basic helix-loop-helix zipper transcription factor that regulates a network of many hundreds of genes. Myc up-regulates the expression of many genes involved in cell growth and proliferation such as ribosome biogenesis and protein synthesi...  Read full blog post.

c-Myc - transcription factor and oncogene
c-Myc is a protein of the Myc family of transcription factors (c-Myc, B-Myc, L-Myc, N-Myc, and s-Myc) encoded by the MYC proto-oncogene. c-Myc was first discovered as the cellular homolog of the retroviral v-Myc oncogene. c-Myc is a transcription...  Read full blog post.

c-Myc. See Myc Run Transcription Regulation
Myc genes (L-Myc, N-Myc and C-Myc) are a family of transcription factors. c-Myc is involved in transcription regulation, apoptosis and cell growth. Mutations in c-Myc have been tied to several cancers. Free sample bonus: Get a free sample on...  Read full blog post.

Beta Catenin Implications for Signaling
The Wnt/beta Catenin signaling pathway plays a critical role in embryonic development, stem cell self-renewal and regeneration. Alterations in this signaling cascade have been implicated in the pathogenesis of cancer. Notably, chronic activation of Wn...  Read full blog post.

Cerebellar Degeneration-Related Protein 2 (CDR2): Cell-Cycle Regulated Tumor Antigen
CDR2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration. CDR2 has also been shown to be a cell cycle r...  Read full blog post.

CIP2A: The Cancerous Inhibitor of Protein Phosphatase 2A
The autoantigen p90 is a recently discovered protein that binds to and inhibits Protein Phosphatase 2A (PP2A) activity, thereby playing a critical role in cancer progression. Thus, p90 was renamed the "cancerous inhibitory protein of PP2A" or CIP2A....  Read full blog post.

Nucleolin Antibodies: Knowing When it's Time to Split
Nucleolin is an abundant, 106 kDa nucleolar phosphoprotein that is a major protein in actively dividing cells. The stability of nucleolin is heavily cell proliferation-dependent, as nucleolin antibody studies have shown that degraded forms are relativ...  Read full blog post.

Showing 1-10 of 14 blog posts - Show all blog posts.

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Bioinformatics

Gene Symbol MYC
Entrez