c-jun Antibody

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Western Blot: c-jun Antibody [NBP1-49691] - Whole cell lysate from 293T (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), HeLa (H; 50 mcg) and mouse NIH3T3 (M; 50 mcg) cells. Affinity purified rabbit ...read more

Product Details

Summary
Product Discontinued
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    • Catalog Number
      NBP1-49691
    • Availability
      Product Discontinued

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c-jun Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 1 and 40 of human Jun Oncogene using the numbering given in entry NP_002219.1 (GeneID 3725).
Clonality
Polyclonal
Host
Rabbit
Gene
JUN
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 2-5 ug/mg lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for c-jun Antibody

  • Activator protein 1
  • AP1
  • AP-1
  • cJun
  • c-Jun
  • enhancer-binding protein AP1
  • Jun activation domain binding protein
  • jun oncogene
  • jun proto-oncogene
  • JUN
  • Proto-oncogene c-Jun
  • transcription factor AP-1
  • V-jun avian sarcoma virus 17 oncogene homologp39
  • v-jun sarcoma virus 17 oncogene homolog (avian)
  • v-jun sarcoma virus 17 oncogene homolog

Background

c-Jun (also known as protooncogene c-jun) is a member of the b-ZIP transcription factor, jun subfamily, containing a leucine zipper domain. This nuclear protein is ubiquitously expressed and binds the enhancer heptamer motif 5'-TGA(C/G)TCA-3 to activate gene expression. c-jun interacts with c-Fos to form a functional transcriptional dimer; Jun deletions and translocations have been observed in human malignancies. c-jun is phosphorylated by JNK1, casein kinase II, and DNA-dependent protein kinase; phosphorylation enhances transcriptional activity. E1A binding protein p300 acetylates and decreases the transcriptional activity of c-jun. There are multiple phosphorylation sites (63, 73, 231, 249) on c-jun and one reported acetylation site (271). C-jun has been reported to interact with CREB binding protein (CBP), CREB, ATF4, c-Fos, STAT1, STAT3 and STAT4, Bcl-3, SMAD3/4 heterodimers, and TCF20. The Poly6065 antibody recognizes mouse and human c-jun and has been shown to be useful for Western blotting.CREB binding protein (CBP), CREB, ATF4, c- Fos, STAT1, 3 and 4, Bcl-3, SMAD3/4 heterodimers, TCF20

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Blogs on c-jun.

Estrogen Related Receptors Play Roles in Cancer and Neurodegeneration
By Eric NeeleyEstrogen receptors come in the form of two distinct forms, ER alpha and ER beta. These nuclear receptors are predominantly activated by the hormone 17-beta-estradiol to control transcription of genes throughout the immune, nervous, car...  Read full blog post.

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Bioinformatics

Gene Symbol JUN
Entrez