c-jun Antibody



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c-jun Antibody Summary

The immunogen for this product maps to a region between residue 1 and 40 of human Jun Oncogene using the numbering given in entry NP_002219.1 (GeneID 3725).
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-buffered Saline and 0.1% BSA
0.09% Sodium Azide
0.2 mg/ml
Immunogen affinity purified

Reactivity Notes

Human, Mouse


c-Jun (also known as protooncogene c-jun) is a member of the b-ZIP transcription factor, jun subfamily, containing a leucine zipper domain. This nuclear protein is ubiquitously expressed and binds the enhancer heptamer motif 5'-TGA(C/G)TCA-3 to activate gene expression. c-jun interacts with c-Fos to form a functional transcriptional dimer; Jun deletions and translocations have been observed in human malignancies. c-jun is phosphorylated by JNK1, casein kinase II, and DNA-dependent protein kinase; phosphorylation enhances transcriptional activity. E1A binding protein p300 acetylates and decreases the transcriptional activity of c-jun. There are multiple phosphorylation sites (63, 73, 231, 249) on c-jun and one reported acetylation site (271). C-jun has been reported to interact with CREB binding protein (CBP), CREB, ATF4, c-Fos, STAT1, STAT3 and STAT4, Bcl-3, SMAD3/4 heterodimers, and TCF20. The Poly6065 antibody recognizes mouse and human c-jun and has been shown to be useful for Western blotting.CREB binding protein (CBP), CREB, ATF4, c- Fos, STAT1, 3 and 4, Bcl-3, SMAD3/4 heterodimers, TCF20


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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By Eric NeeleyEstrogen receptors come in the form of two distinct forms, ER alpha and ER beta. These nuclear receptors are predominantly activated by the hormone 17-beta-estradiol to control transcription of genes throughout the immune, nervous, car...  Read full blog post.

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Gene Symbol JUN

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