Western blot (WB) analysis of ubR1 (T368) pAb in extracts from HeLa cells treated with H2O2 100uM 30'.
130 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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The N-end rule relates the in vivo half-life of a protein to the composition of its N-terminal residues. The N-end rule pathway is part of the ubiquitin system, which involves a three-step mechanism. Proteins targeted for degradation are bound on their N-terminal residue by Ubr1 (also designated E3 alpha and N-recognin), which catalyzes the covalent attachment of ubiquitin to the protein substrate. Two zinc finger domains and the RING-H2 finger domain of Ubr1 are essential for substrate recognition. Ubr1 is located on mouse chromosome 2 and on human chromosome 15 in the syntenic region. Ubr1 is a 220 kDa protein that is ubiquitously expressed in adult mouse, with the highest expression detected in skeletal muscle and heart. In mouse embryo, Ubr1 is primarily expressed in the branchial arches and in the tail and limb buds.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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