BTBD7 Blocking Peptide

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-49654
    • Availability
      Product Discontinued

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BTBD7 Blocking Peptide Summary

Description
Synthetic peptide corresponding to unique epitope on Btbd7 protein between aa 1095-1138. The peptide sequence selected was post synthetically modified to achieve desired antigenicity before covalently coupling to a carrier protein.

NCBI Accession #: NP_001002860

Source: Synthetic

Source
Synthetic
Protein/Peptide Type
Blocking Peptide
Gene
BTBD7
Purity
>85%, by HPLC

Applications/Dilutions

Application Notes
This peptide is useful as a blocking peptide for NBP1-49652. For further blocking peptide related protocol, click here. Applications: Immmunodepletion, Competition Assay

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Sodium Bicarbonate buffer, pH 8.00 containing up to 10% DMSO
Concentration
2.5 mg/ml
Purity
>85%, by HPLC

Alternate Names for BTBD7 Blocking Peptide

  • BTB (POZ) domain containing 7
  • DKFZp686N0544
  • FLJ10648
  • FUP1BTB/POZ domain-containing protein 7
  • KIAA1525
  • MGC48310

Background

Cancer cells especially human hepatocellular carcinoma (HCC) differentially express many genes as determined by cDNA microarrays. One of these genes is Btbd7 whose function was not known. When transfected in NIH3T3 cells this gene exhibited enhanced cell proliferation activity by MTT assay. The enhanced tumorigencity was blocked by anti-sense RNA experiments (1). Recently it has been shown that Btbd7 regulate epithelial cell dynamics and branching morphogenesis. The organ development during embryogenesis requires extensive branching of epithelia via formation of cleft and buds. These branches are developed by local outgrowth or by formation of cleft that further divide epithelia in to buds. The bud or tubule extension is controlled and regulated by various growth factors. These branching finally led to formation of various organs. Cellular matrix protein fibronectin is required for salivary, lung and kidney branching (3). The edges of fibronectin translocates inwards as cleft accompanied by loss of E-cadherin in cells adjacent to fibronectin. The Btbd7 activity was noticed at cell cleft forming sites (2). The cleft formation involves buds delineation of buds by conversion of epithelial cell-cell adhesion to cell-matrix adhesion. Btbd7 provides a mechanistic link between the extracellular matrix and cleft propagation via its highly discrete expression that control epithelial cell motility by interaction with other cellular architectural and scaffolding proteins like Snail2 (slug), E-cadherin (4). The Btbd7 antibodies were generated using peptide corresponding to C-terminal domain of the human Btbd7 gene. The Btbd7 antibodies are affinity purified over immobilized antigen based affinity chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer. Antibodies to Btbd7 (Btbd-701AP) will label ~144kDa protein in Western blot positive control for Btbd7 (PC-Btbd7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Product General Protocols

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Additional Array Products

Array NBP1-49654

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Bioinformatics

Gene Symbol BTBD7