BRCA1 [p Ser1423] Antibody Summary
Synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Serine 1423.
p-BRCA1 (S1423) pAb detects endogenous levels of BRCA1 protein only when phosphorylated at S1423.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline (PBS) approx. pH 7.2.
0.05% Sodium Azide
Immunogen affinity purified
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:50-1:200
Immunohistochemistry (IHC) analyzes of p-BRCA1 (S1423) pAb in paraffin-embedded human breast carcinoma tissue.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Cross reacts with Human and Rat.
Alternate Names for BRCA1 [p Ser1423] Antibody
- breast and ovarian cancer susceptibility protein 1
- breast and ovarian cancer sususceptibility protein
- breast cancer 1, early onset
- breast cancer type 1 susceptibility protein
- EC 6.3.2
- EC 6.3.2.-
- subunit 1
BRCA1 is a cell cycle-regulated nuclear protein that is phosphorylated mainly
on Serine and to a lesser extent on Threonine residues. Changes in phosphorylation
occur in response to cell cycle progression and DNA damage. BRCA1
undergoes hyperphosphorylation during late G1 and S phases of the cell cycle.
BRCA1 is a substrate of ATM kinase, and phosphorylation of BRCA1 requires
the presence of a functional ATM protein. Chk2 regulates BRCA1 function
after DNA damage by phosphorylating serine 988 of BRCA1. This phosphorylation
is required for the release of BRCA1 from Chk2 and the ability of
BRCA1 to restore survival after DNA damage. BRCA1 is also phosphorylated
at Serine 1497, which is part of a cyclin-dependent kinase consensus site.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Applications: WB, IHC
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt, Av, Bv, Pm
Applications: WB, B/N, Flow, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Applications: WB, Flow
Applications: WB, ICC
Species: Hu, Mu, Ce, Ch
Applications: WB, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt, Bv, Ch, GP, Pm, Rb, Sh
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Applications: WB, Simple Western, ICC
Species: Hu, Mu, Rt, Pm
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
Applications: WB, IP, PLA
Species: Hu, Mu, Ha, Ma, Pm
Applications: WB, ChIP, Flow, ICC/IF, IHC, IP
Applications: WB, ICC/IF
Species: Hu, Mu, Rt, Fi, Gt, Pm
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu
Applications: WB, IB, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt, Ca
Applications: IP (-), WB, Simple Western, Flow, ICC/IF, IHC, IHC-P
Applications: WB, Func, ICC/IF, IP
Species: Hu, Rt
Applications: IHC, IHC-P
Publications for BRCA1 Antibody (NBP1-51452) (0)
There are no publications for BRCA1 Antibody (NBP1-51452).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for BRCA1 Antibody (NBP1-51452) (0)
There are no reviews for BRCA1 Antibody (NBP1-51452).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for BRCA1 Antibody (NBP1-51452) (0)
Additional BRCA1 [p Ser1423] Antibody Products
Related Products by Gene
Bioinformatics Tool for BRCA1 Antibody (NBP1-51452)
Discover related pathways, diseases and genes to BRCA1 Antibody (NBP1-51452). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on BRCA1. Showing 1-10 of 18 blog posts - Show all blog posts.
The recent relationship of BRCA1 and 53BP1
The p53-binding protein 1 (53BP1) is a DNA damage response factor, which is recruited to nuclear structures at the site of DNA damage. DNA double-strand breaks (DSBs) are mutations that are detrimental to cell viability and genome stability, and m... Read full blog post.
ATM - detecting and responding to DNA damage
Ataxia telangiectasia mutated (ATM) is essential for the maintenance of genomic stability. ATM is a 370 kDa serine-threonine kinase that is constitutively expressed in various tissues. Although primarily nuclear, ATM is also found at lower levels... Read full blog post.
FANCD2 (Fanconi anemia subunit D2 protein)
Fanconi anemia (FANC) is a rare, autosomal-recessive genetic disorder that is a heterogeneous cancer susceptibility condition that manifests with a wide range of symptoms such as congenital malformations, deteriorating bone marrow failure, DNA-dama... Read full blog post.
53BP1 - a marker for DNA Double Strand Break
53BP1 (p53 binding protein 1) was originally thought to be an enhancer for p53 transcriptional, but later studies have demonstrated that it is actually a substrate for ataxia telangiectasia mutated (ATM). 53BP1 is a classic late DNA damage response... Read full blog post.
FANCD2: A big component of the DNA repair crew
The genetic disorder known as Fanconi anemia (FANC) is a heterogeneous, autosomal-recessive cancer susceptibility condition characterized by a wide array of symptoms. These include congenital malformations, progressive bone marrow failure, DNA-damage... Read full blog post.
BRCA1 - A Critical Tumor Suppressor Gene in Women
Breast cancer 1, early onset (BRCA1) is a well-known tumor suppressor gene that was originally discovered due to its link with early-onset breast and ovarian cancer in women. The BRCA1 protein contains the following domains: RING finger, RAD51-interac... Read full blog post.
53BP1 - DNA damage is no fun
The 53BP1 (p53 binding protein 1) was initially believed to be a p53 transcriptional enhancing partner, but it has now been established as an ataxia telangiectasia mutated (ATM) substrate. As a late DNA damage response (DDR) marker, 53BP1 appears duri... Read full blog post.
Breast Cancer Infographic
Breast cancer is caused by malignant cells developing in breast tissue. It is the most commonly diagnosed cancer in women, but advancements in treatment options have seen the death rate decline since the 1990s. Common warning signs of breast cancer in... Read full blog post.
COBRA1: A Key Player in Transcriptional Pausing
Co-factor of BRCA1, also known as COBRA1, was first identified as a protein that binds to the tumour suppressor protein encoded by the breast cancer susceptibility gene BRCA1 (1). It was subsequently found to be identical to subunit B of the Negative... Read full blog post.
RAD51: The cell's 'Mr. Fix-it'
RAD51 is a recombinase protein encoded by RAD51 gene in humans. Human RAD51 family members are highly similar to bacterial RecA and yeast Rad51, both biochemically and structurally. It is a 339-amino acid protein that plays an important role in homolo... Read full blog post.