BIK Antibody

Images

 
Western Blot: Bik Antibody [NB100-91678] - Extracts from A549 cell treated with DMSO 0.1% 10' cells.
Immunohistochemistry-Paraffin: Bik Antibody [NB100-91678] - Paraffin-embedded human lung carcinoma tissue.

Product Details

Summary
Product Discontinued
View other related BIK Primary Antibodies

Order Details


    • Catalog Number
      NB100-91678
    • Availability
      Product Discontinued

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BIK Antibody Summary

Immunogen
Synthetic peptide, corresponding to the N-terminal of Human BIK.
Clonality
Polyclonal
Host
Rabbit
Gene
BIK
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of BIK (M27) pAb in extracts from A549 cell treated with DMSO 0.1% 10' cells.
Immunohistochemistry (IHC) analyzes of BIK (M27) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
23 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for BIK Antibody

  • Apoptosis inducer NBK
  • BCL2-interacting killer (apoptosis-inducing)
  • bcl-2-interacting killer
  • BIK
  • BIP1
  • BP4
  • NBK
  • NBKapoptosis-inducing NBK

Background

Bik/Nbk (Bcl-2-interacting killer/natural born killer) is a potent pro-apoptotic protein belonging to a group of Bcl-2 family members that includes Bad, Bid, Bim, Hrk, and Noxa, containing a BH3 domain but lacking other conserved domains, BH1 or BH2 (1,2). Functionally, Bik is able to bind to and antagonize anti-apoptotic Bcl-2 family members including Bcl-2, Bcl-xL, and viral homologs E1B-19K and EBV-BHFR1. The BH3 domain of Bik is essential for its apoptotic activity and interaction with survival proteins (3). Phosphorylation of Bik is correlated with an increase in its pro-apoptotic activity (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BIK Antibody (NB100-91678) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for BIK Antibody (NB100-91678)

Discover related pathways, diseases and genes to BIK Antibody (NB100-91678). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for BIK Antibody (NB100-91678)

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Bioinformatics

Gene Symbol BIK
Entrez