beta-Synuclein Antibody

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Immunohistochemistry-Paraffin: Synuclein-beta Antibody [NBP1-36557] - Human Brain.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-36557
    • Availability
      Product Discontinued

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beta-Synuclein Antibody Summary

Immunogen
A synthetic peptide derived from near C-terminus of human -Synuclein.
Specificity
This product is specific for Synuclein beta
Clonality
Polyclonal
Host
Rabbit
Gene
SNCB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100
Application Notes
This product is useful for Immunohistochemistry Paraffin. If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution). Use recommended dilution for the concentrated vials only.

Reactivity Notes

This product is specific for Human, Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4)
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for beta-Synuclein Antibody

  • beta-Synuclein
  • SNCB
  • synuclein, beta
  • Synuclein-beta

Background

The beta-synuclein protein is highly homologous to the alpha-synuclein protein for which two mutations were reported in some familial cases of Parkinson disease. It has been shown that both alpha- and beta-synucleins may be able to inhibit phospholipase D2 selectively (1). Recent studies have shown that the neurodegenerative process in disorders with Lewy body formation, such as Parkinson's disease and dementia with Lewy bodies, is associated with alpha-synuclein accumulation and that beta-synuclein might protect the central nervous system from the neurotoxic effects of alpha-synuclein (2). results raise the possibility that beta-synuclein might be a natural negative regulator of alpha-synuclein aggregation and that a similar class of endogenous factors might regulate the aggregation state of other molecules involved in neurodegeneration. Such an anti-amyloidogenic property of beta-synuclein might also provide a novel strategy for the treatment of neurodegenerative disorders (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SNCB
Entrez