beta-Catenin Antibody

Images

 
Immunohistochemistry-Paraffin: beta Catenin Antibody [NBP1-52328] - Staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more
Immunohistochemistry-Paraffin: beta Catenin Antibody [NBP1-52328] - Staining of human skin, hair follicle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more
Immunohistochemistry-Paraffin: beta Catenin Antibody [NBP1-52328] - Staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration ...read more
Immunohistochemistry-Paraffin: beta Catenin Antibody [NBP1-52328] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration ...read more

Product Details

Summary
Product Discontinued
View other related beta-Catenin Primary Antibodies

Order Details


    • Catalog Number
      NBP1-52328
    • Availability
      Product Discontinued

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beta-Catenin Antibody Summary

Immunogen
Synthesized non-phosphopeptide derived from human beta-Catenin around the phosphorylation site of serine 37 (I-H-SP-G-A).
Marker
Epithelial Cell Marker, Adherens Junction Marker
Specificity
Endogenous levels of total beta-Catenin protein.
Clonality
Polyclonal
Host
Rabbit
Gene
CTNNB1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Immunoprecipitation 1:10-1:500
Positive Control
beta-Catenin Lysate (NBP2-64913)

Reactivity Notes

Human. Predicted cross-reactivity to Mouse and Rat.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for beta-Catenin Antibody

  • bCatenin
  • beta 1 (88kD)
  • beta-Catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin beta-1
  • CTNNB
  • CTNNB1
  • DKFZp686D02253
  • FLJ25606
  • FLJ37923

Background

Beta-catenin is an adherens junction protein, which mediates cell-cell adhesion, cell-cell communication and contributes to cytoskeletal integrity. It is similar to the product of the Drosophila segment polarity gene armadillo. Like armadillo, beta-catenin is part of the E cadherin multiprotein complex that regulates pattern formation at several stages of embryogenesis. In addition beta-catenin is involved in wound healing and tumor cell metastasis. Beta-catenin is part of the Wnt signaling cascade. It interacts with Tcf and Lef to activate gene transcription and regulates cell growth. Beta-catenin accumulation has been observed in various cancers, especially in colorectal tumors and hepatoblastoma. Beta-catenin-mediated transcription is down regulated when the protein binds to the tumor suppressor protein APC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for beta-Catenin Antibody (NBP1-52328)

Discover related pathways, diseases and genes to beta-Catenin Antibody (NBP1-52328). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on beta-Catenin.

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma
By Jamshed Arslan Pharm.D. Multiple myeloma (MM) is a cancer of antibody-producing plasma cells. The bone marrow (BM) of MM patients is hypoxic, and MM cells overexpress many cancerous genes that are regulated by hy...  Read full blog post.

Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...  Read full blog post.

CD63: is it pro-metastatic or anti-metastatic?
CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,...  Read full blog post.

Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process...  Read full blog post.

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Bioinformatics

Gene Symbol CTNNB1
Entrez
Uniprot