beta-2 Adrenergic R/ADRB2 Antibody

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Immunohistochemistry-Paraffin: beta-2 Adrenergic R/ADRB2 Antibody [NLS2662] - Analysis of anti-ADRB2 antibody with human brain, cerebellum at dilution 2.8 - 4.6 ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NLS2662
    • Availability
      Product Discontinued

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beta-2 Adrenergic R/ADRB2 Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human ADRB2.
Localization
Cell Membrane
Specificity
Human ADRB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Clonality
Polyclonal
Host
Rabbit
Gene
ADRB2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 2.8 - 4.6 ug/ml
Publications
Read Publications using
NLS2662 in the following applications:

  • IHC
    2 publications

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (88%), Gorilla (88%), Marmoset (88%), Mouse (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for beta-2 Adrenergic R/ADRB2 Antibody

  • ADRB2
  • ADRB2R
  • ADRBR
  • adrenergic, beta-2-, receptor, surface
  • B2AR
  • B2ARADRB2R
  • BAR
  • beta-2 Adrenergic R
  • beta-2 adrenergic receptor
  • beta2 AdrenergicR
  • beta-2 AdrenergicR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
  • BETA2AR
  • catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for beta-2 Adrenergic R/ADRB2 Antibody (NLS2662)(2)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: IHC.


Filter By Application
IHC
(2)
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Filter By Species
Rat
(2)
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Secondary Antibodies

 

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Diseases for beta-2 Adrenergic R/ADRB2 Antibody (NLS2662)

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Bioinformatics

Gene Symbol ADRB2
Entrez