Bcl-10 Antibody (SP153)

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Immunohistochemistry-Paraffin: Bcl10 Antibody (SP153) [NBP2-21750] - Humna MALT B-Cell Lymphoma.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
SP153
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Bcl-10 Antibody (SP153) Summary

Immunogen
Synthetic peptide in the internal region of the human BCL-10.
Localization
Cytoplasm, Nucleus
Clonality
Monoclonal
Host
Rabbit
Gene
BCL10
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100

Reactivity Notes

Tested in Human. Based on sequence identity cross reactivity is expected with Bovine, Mouse, Porcine and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.6) and 1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Protein G purified

Alternate Names for Bcl-10 Antibody (SP153)

  • B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10
  • Bcl10
  • Bcl-10
  • CARD-containing apoptotic signaling protein
  • CARD-containing molecule enhancing NF-kappa-B
  • CARD-containing proapoptotic protein
  • CARD-like apoptotic protein
  • CARMEN
  • caspase-recruiting domain-containing protein
  • cCARMEN
  • c-E10
  • c-E10bcl-10
  • CED-3/ICH-1 prodomain homologous E10-like regulator
  • Cellular homolog of vCARMEN
  • cellular-E10
  • CIPER
  • CLAP
  • hCLAP
  • Mammalian CARD-containing adapter molecule E10
  • mE10
  • mE10CARD containing molecule enhancing NF-kB

Background

BCL-10 is expressed at different evel in the cytoplasm of most normal human cells and translocates into the nucleus in MALT lymphoma, especially in those with translocation (1; 14)(p22;q32). BCL-10 and MALT-1 protein form a complex in MALT lymphoma and are thought to synergize in the activation of NF-kappaB. The deregulation of either of them may contribute to the same pathogenic process that leads to the malignancy. BCL-10 contains a caspase-recruiting (CARD) domain and is involved in activation of caspase-9 to induce apoptosis. Mutations in BCL-10 are observed in some B and T cell lymphomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol BCL10
Entrez