BAFFR/TNFRSF13C Antibody (204406) [Alexa Fluor® 594]


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Product Details

Reactivity MuSpecies Glossary
Applications Flow
Alexa Fluor 594
Please see the vial label for concentration. If unlisted please contact technical services.

BAFFR/TNFRSF13C Antibody (204406) [Alexa Fluor® 594] Summary

Mouse myeloma cell line NS0-derived recombinant mouse BAFF R/TNFRSF13C
Accession # Q9D8D0
Detects mouse BAFF R/TNFRSF13C in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant human (rh) BAFF R is observed, approximately 10‑25% cross-reactivity with recombinant mouse (rm) 4‑1BB, rmDR3, rhDR6, rmEDAR, rhHVEM, rmNGF R, rmOX40, and rmTROY is observed, and no cross-reactivity with rmCD27, rmCD30, rmCD40, rmFAS, rmGITR, rmLymphotoxin  beta R, rmOPG, rmRANK, rmTNFRI, or rmTNF RII is observed.
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  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BAFFR/TNFRSF13C Antibody (204406) [Alexa Fluor® 594]

  • BAFF R
  • BR3
  • CD268


B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. It is produced by macrophages, dendritic cells, and T lymphocytes. BAFF promotes the survival of B cells and is essential for B cell maturation (1‑4). BAFF binds to three TNF receptor superfamily members: B‑cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF-R selectively binds BAFF. Mouse BAFF-R cDNA encodes a 175 amino acid residue (aa) transmembrane protein with a 71 aa extracellular domain, a 21 aa transmembrane domain, and a 83 aa cytoplasmic region. A second isoform of BAFF R that has a 72 aa cytoplamic region can also be produced by alternative splicing. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cells, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells and has profound defects in antibody mediated immune responses. Similarly, A/WySnJ mice that are defective in BAFF R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. In contrast, BCMA- or TACI-deficient mice have no major defect in B‑cell development. While the function of BCMA is not defined, TACI has been shown to control
B-cell homeostasis and T-cell-independent immune responses.

  1. Rolink, A.G. and F. Melcher (2002) Curr. Opin. Immunol. 14:266.
  2. Mackay, F. and J.L. Browning (2002) Nature Reviews Immunology 2:464.
  3. Laabi, Y. et al. (2001) Current Biol. 11:R1013.
  4. Thompson, J.S. et al. (2001) Science 14:2108.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB1755U
Alexa Fluor 405 FAB1755V
Alexa Fluor 488 FAB1755G
Alexa Fluor 594 FAB1755T
Alexa Fluor 647 FAB1755R
Alexa Fluor 700 FAB1755N
Alexa Fluor 750 FAB1755S

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Gene Symbol TNFRSF13C