BAFF/BLyS/TNFSF13B Partial Recombinant Protein Summary
A partial protein corresponding to TNFSF13B.
E. coli expressed amino acids Ala134 - Leu285 (Accession # Q9Y275).
|Details of Functionality
The ED50, as determined by a mouse splenocyte survival assay, is 1.6 ug/ml.
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sterile liquid; 10 mM Phosphate, 150 mM NaCl with 1.0% BSA. 0.22 um filtered.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This protein was made to the human sequence.
Alternate Names for BAFF/BLyS/TNFSF13B Partial Recombinant Protein
- ApoL related ligand TALL-1
- B lymphocyte stimulator
- BAFFB-cell activating factor
- B-cell-activating factor
- BLYSB-lymphocyte stimulator
- CD257 antigen
- Dendritic cell-derived TNF-like molecule
- TALL-1delta BAFF
- TALL1Delta4 BAFF
- TNF- and APOL-related leukocyte expressed ligand 1
- TNF and ApoL-related leukocyte expressed ligand 1
- TNF homolog that activates apoptosis
- tumor necrosis factor (ligand) superfamily, member 13b
- tumor necrosis factor (ligand) superfamily, member 20
- tumor necrosis factor ligand superfamily member 13B
- tumor necrosis factor superfamily, member 13b
- tumor necrosis factor-like protein ZTNF4
Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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